Arteriosclerosis obliterans (ASO) is a serious complication in patients with end-stage renal disease (ESRD) caused by diabetic nephropathy. Adsorption of low-density lipoprotein (LDL) has been performed to treat ASO. While efficacy of this treatment has been reported in limb ischemia, the mechanism underlying the benefit remains unclear. We investigated how LDL adsorption affected soluble adhesion molecules; P-selectin, an endothelial and platelet activation marker; inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tissue necrosis factor (TNF)-alpha; and lipids in serum.
Selective LDL adsorption by dextran sulfate columns (LDL apheresis) was performed weekly for 10 weeks to treat eight hemodialysis patients with ASO, ESRD, and type 2 diabetes mellitus. Serum was sampled before and immediately after apheresis.
LDL apheresis was performed safely. After LDL apheresis lipid concentrations were significantly reduced and clinical findings, such as Fontaine's classification and ankle brachial pressure index values, were improved. Pretreatment concentrations of soluble intercellular and vascular cell adhesion molecules (sICAM-1 and sVCAM-1) and also P-selectin were higher in patients than healthy controls. After apheresis these decreased, especially P-selectin. IL-1beta, IL-6, and TNF-alpha concentrations before apheresis were similar to those in controls and were unaffected by treatment.
Effectiveness of LDL apheresis against ASO may involve decreased endothelial cell and platelet activation.
[Show abstract][Hide abstract] ABSTRACT: Summary form only given. We present an experimental and theoretical investigation of ultrafast transient four-wave mixing (TFWM) of GaAs-AlGaAs quantum wells for simultaneous excitation of exciton and continuum states. Recent TFWM experiments on semiconductors have shown unexpected results when both discrete exciton states and continuum states have been excited simultaneously by ultrafast laser pulses. The decay of the signal, as a function of delay, is significantly faster than the dephasing time of the excitons.
Quantum Electronics and Laser Science Conference, 1996. QELS '96., Summaries of Papers Presented at the; 07/1996
[Show abstract][Hide abstract] ABSTRACT: To compete, successful companies must often integrate technical
expertise or disciplines from outside their traditional areas of
operation. Virtual organizations are formed, combining individuals and
companies with widely divergent viewpoints and methods of operation. By
their very nature, these teams face challenges in operating effectively
and staying focused on overall goals. The paper presents the process
used by a virtual team comprised of employees from Genta and Procter and
Gamble (P&G) to establish and develop a successful long distance
Engineering and Technology Management, 1996. IEMC 96. Proceedings., International Conference on; 09/1996
Jihui Chen, Wentong Cui, Quanbin Zhang, Yingli Jia, Yi Sun, Lin Weng, Dali Luo, Hong Zhou, Baoxue Yang
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.