Antiplasmodial and GABA(A)-benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa

Department of Pharmaceutical Chemistry, University of Oslo, Kristiania (historical), Oslo, Norway
Journal of Ethnopharmacology (Impact Factor: 3). 05/2007; 110(3):451-7. DOI: 10.1016/j.jep.2006.10.019
Source: PubMed


Extracts of five medicinal plants: Boscia angustifolia, Cissus quadrangularis, Securidaca longipedunculata, Stylosanthes erecta and Trichilia emetica, used traditionally in Malian traditional medicine were screened for in vitro antiplasmodial activity and GABA(A)-benzodiazepine receptor binding activity. Four extracts showed significant antiplasmodial activities, with the dichloromethane extract of leaf of Securidaca longipedunculata being the most active (IC(50) of 7 microg/ml [95% CI: 5-9]). The dichloromethane extract of leaf of Trichilia emetica, in addition to its antiplasmodial activity (IC(50): 12 microg/ml [95% CI: 12-14]), exhibited a good binding activity to the GABA(A)-benzodiazepine receptor, while water and methanol extracts of the same plant did not show any activity. A strong GABA(A)-receptor complex binding activity was observed in the methanol extract of aerial part of Stylosanthes erecta. The results in this study justify some of the traditional indications of the plants investigated and may thus be candidates for Improved Traditional Medicines in Mali.

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    • "C. quadrangularis is available throughout the year. The plant has been reported to possess wound healing (Mohanty et al., 2010), antiostoporotic (Shirwaikar et al., 2003), antioxidant (Chidambara et al., 2003), antipseudomonal and antibacterial (Kashikar and George, 2006), ulcer protective (Jainu and Devi, 2006a), antiplasmodial (Bah et al., 2007), anti-inflammatory (Jainu et al., 2006b; Jainu et al., 2006c; Panthong et al., 2007) and analgesic activity (Priyanka et al., 2010). Use of plants as a sourse of medicine has been inherited and is an important component of the health care system in India. "
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