Antiplasmodial and GABA(A)-benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa.
ABSTRACT Extracts of five medicinal plants: Boscia angustifolia, Cissus quadrangularis, Securidaca longipedunculata, Stylosanthes erecta and Trichilia emetica, used traditionally in Malian traditional medicine were screened for in vitro antiplasmodial activity and GABA(A)-benzodiazepine receptor binding activity. Four extracts showed significant antiplasmodial activities, with the dichloromethane extract of leaf of Securidaca longipedunculata being the most active (IC(50) of 7 microg/ml [95% CI: 5-9]). The dichloromethane extract of leaf of Trichilia emetica, in addition to its antiplasmodial activity (IC(50): 12 microg/ml [95% CI: 12-14]), exhibited a good binding activity to the GABA(A)-benzodiazepine receptor, while water and methanol extracts of the same plant did not show any activity. A strong GABA(A)-receptor complex binding activity was observed in the methanol extract of aerial part of Stylosanthes erecta. The results in this study justify some of the traditional indications of the plants investigated and may thus be candidates for Improved Traditional Medicines in Mali.
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ABSTRACT: Dysmenorrhea is painful menstrual cramps, which negatively impacts the quality of life of a large percentage of the world's female population in reproductive age. The paper reviews the plants used in the Malian traditional medicine for the treatment of dysmenorrhea. Some medicinal plants were effective for treatments of dysmenorrhea with minimal side effects. Conventional therapy for dysmenorrhea, which usually includes non-steroidal anti-inflammatory drugs (NSAIDs), provides symptomatic relief, but presents increasing adverse effects with long-term use. This article is in the framework of a study supported by International Foundation for Science (IFS) on three medicinal plants used in the treatment of dysmenorrhea in Mali: Maytenus senegalensis Stereospermum kunthianum and Trichilia emetica.African Journal of Traditional, Complementary and Alternative Medicines 07/2011; 8(5 Suppl):90-6. · 0.52 Impact Factor
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ABSTRACT: Cissus quadrangularis L. (Vitaceae) is a common perennial climber, which is distributed throughout Bangladesh. Though almost all of its parts are used in traditional systems of medicines seeds, stem, roots and shoots are the most important parts which are used medicinally. The article reveals that wide numbers of phytochemical constituents have been isolated from the plant which possesses activities like anti‑inflammatory, anti‑tumor, gastro‑protective, antioxidant, antimicrobial and various other important medicinal properties. The stem juice of plant is used in menstrual disorders, epistaxis and leaves is used against bowel infections. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The current review deals with the enormous amount of updated information of scientific research and reports available in different aspects of this plant involving phytochemical and pharmacology. This review also includes reports on taxonomy, morphology, monographs, distribution, tissue culture and traditional medicinal uses of the plant. Key words: Cissus quadrangularis, phytochemical constituents, pharmacological activity, traditional usesInternational Journal of Green Pharmacy 09/2012;
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ABSTRACT: The present study was performed to explore the antihyperglyceamic activity of ethanolic extract of leaves of Cissus quadrangularis against alloxan induced diabetic rats. Ethanolic extract of C. quadrangularis and glyburide were administered orally in alloxan induced diabetic rats. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimated at 7, 14, 21 and 28 days. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic rats half an hour after pre-treatment with EtCQ and glyburide. Serum glucose levels were estimated 30 min prior to glucose administration and at 0, 30, 60 and 120 min after glucose loading. In EtCQ (400 mg/kg), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In subacute study, repeated administration (once a day for 28 days) of the glyburide and EtCQ caused a significant reduction in the serum glucose level as compared to the vehicle treated group. EtCQ (400 mg/kg) treatment prevented a decrease in the body weight of the diabetic rats. In the OGTT, EtCQ (200 & 400 mg/kg) increased the glucose threshold at 30 min after the administration of glucose. The EtCQ (400 mg/kg) showed significant antihyperglyceamic activity than EtCQ (100 and 200 mg/kg). It can be concluded that ethanolic extract of C. quadrangularis has antihyperglyceamic activity.Journal of Applied Pharmaceutical Sciences. 01/2013; 3(1):73-77.