Article

A Pilot Study of Quetiapine Treatment of Aggression Due to Traumatic Brain Injury

Bristol-Myers Squibb, New York, New York, United States
Journal of Neuropsychiatry (Impact Factor: 2.77). 02/2006; 18(4):547-9. DOI: 10.1176/appi.neuropsych.18.4.547
Source: PubMed

ABSTRACT In a 6-week open-label, flexible dose pilot study of quetiapine for treatment of aggression secondary to traumatic brain injury (TBI), seven subjects who were at least 3-months post-injury were enrolled. The Overt Aggression Scale - Modified (OAS-M) and Clinical Global Impression (CGI) were primary outcome measures. Administration of quetiapine at doses of 25 to 300 mg daily was efficacious and well-tolerated in reducing irritability and aggression resulting from TBI, with an associated improvement in cognitive functioning.

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    • "It is also safe regarding extrapyramidal side effects6,33,52,61). Clinical studies have revealed that quetiapine is also a suitable agent for the treatment of aggression and agitation due to traumatic cerebral damage39). Quetiapine causes blockage with its high binding affinity for serotonin 5-HT2 and 5-HT6 receptors and the more moderate affinity for dopamine D2 receptors. It also has affinity towards α1 and α2 receptors and H1 receptors like clozapine. "
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