eIF4A goes beyond translation
Nature Cell Biology (Impact Factor: 19.68). 01/2007; 8(12):1319-21. DOI: 10.1038/ncb1206-1319
A new study has revealed an unexpected role for eukaryotic translation initiation factor 4A (eIF4A) in suppressing Decapentaplegic (Dpp) signalling. On activation of Dpp signalling, eIF4A promotes degradation of the downstream signalling components Mad and Medea in a translation-independent manner.
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ABSTRACT: The development of multicellular organisms requires the well balanced and coordinated migration of many cell types. This is of particular importance within the developing nervous system, where glial cells often move long distances to reach their targets. The majority of glial cells in the peripheral nervous system of the Drosophila embryo is derived from the CNS and migrates along motor axons toward their targets. In the developing Drosophila eye, CNS-derived glial cells move outward toward the nascent photoreceptor cells, but the molecular mechanisms coupling the migration of glial cells with the growth of the eye imaginal disc are mostly unknown. Here, we used an enhancer trap approach to identify the gene spinster, which encodes a multipass transmembrane protein involved in endosome-lysosome trafficking, as being expressed in many glial cells. spinster mutants are characterized by glial overmigration. Genetic experiments demonstrate that Spinster modulates the activity of several signaling cascades. Within the migrating perineurial glial cells, Spinster is required to downregulate Dpp (Decapentaplegic) signaling activity, which ceases migratory abilities. In addition, Spinster affects the growth of the carpet cell, which indirectly modulates glial migration.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 05/2011; 31(19):7005-15. DOI:10.1523/JNEUROSCI.0459-11.2011 · 6.34 Impact Factor
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