Article

Fungal brain abscesses in leukemia.

2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
Indian pediatrics (impact factor: 1.05). 12/2006; 43(11):991-4. pp.991-4
Source: PubMed

ABSTRACT Invasive fungal infections remain a life threatening complication in children with hematological malignancies. The brain represents a common site of hematogenously disseminated infections from an extracranial focus. We report our experience in the diagnosis, radiological aspects and therapeutic approach of fungal brain abscesses in 2 children receiving chemotherapy for acute lymphoblastic leukemia (ALL).

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    Article: Microbiological spectrum of brain abscess at a tertiary care hospital in South India: 24-year data and review.
    V Lakshmi, P Umabala, K Anuradha, K Padmaja, C Padmasree, A Rajesh, A K Purohit
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    ABSTRACT: Intracranial abscesses are life-threatening infections that pose a diagnostic challenge not only to the neurosurgeon but also to the microbiologists. Detailed studies documenting the spectrum of infecting agents involved in brain abscesses are limited from India. Materials and Methods. This is a retrospective analysis of 352 samples from 1987 to 2010 analyzed at a tertiary care hospital in South India from 1987 to 2010, to document the changing trends with time. Results. The age of the patients ranged from 2 to 80 years, a larger number of males being affected. Otogenic infections were the most common cause while cryptogenic abscesses were 20%. Gram stain and culture positivity were 78% each. Gram-positive and negative facultative aerobes and obligate anaerobes were also on the rise. Unusual organisms, like Burkholderia pseudomallei, Salmonella typhi, Nocardia species, Cladosporium bantiana, Fonsecaea pedrosoi, Entamoeba histolytica, and Acanthamoeba were also isolated and/or detected from the brain abscesses aspirate or resected tissue. Summary. New and emerging pathogens associated with brain abscess, especially in immunosuppressed individuals, have renewed the necessity of an early detection, and it will be of great value in appropriate management of patients with brain abscess.
    Pathology research international. 01/2011; 2011:583139.
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Keywords

2 children
 
acute lymphoblastic leukemia
 
common site
 
extracranial focus
 
fungal brain abscesses
 
hematological malignancies
 
Invasive fungal infections
 
radiological aspects
 

Fani Athanassiadou