Dietary Flavonoid Intake and Breast Cancer Risk among Women on Long Island

Department of Epidemiology, Columbia University, New York, New York, United States
American Journal of Epidemiology (Impact Factor: 5.23). 04/2007; 165(5):514-23. DOI: 10.1093/aje/kwk033
Source: PubMed


Flavonoids are found in a variety of foods and have anticarcinogenic properties in experimental models. Few epidemiologic studies have examined whether flavonoid intake is associated with breast cancer in humans. In this study, the authors investigated whether dietary flavonoid intake was associated with reduced risk of breast cancer in a population-based sample of US women. They conducted a case-control study among women who resided in Nassau and Suffolk counties on Long Island, New York. Cases and controls were interviewed about known and suspected risk factors and asked to complete a food frequency questionnaire regarding their average intake in the prior 12 months. A total of 1,434 breast cancer cases and 1,440 controls provided adequate responses. A decrease in breast cancer risk was associated with flavonoid intake; the decrease was most pronounced among postmenopausal women for flavonols (odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.40, 0.73), flavones (OR = 0.61, 95% CI: 0.45, 0.83), flavan-3-ols (OR = 0.74, 95% CI: 0.55, 0.99), and lignans (OR = 0.69, 95% CI: 0.51, 0.94). The authors conclude that intake of flavonols, flavones, flavan-3-ols, and lignans is associated with reduced risk of incident postmenopausal breast cancer among Long Island women. These results suggest that US women can consume sufficient levels of flavonoids to benefit from their potential chemopreventive effects.

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    • "Reduced mortality with higher intake of total flavonoids, isoflavones, anthocyanidins Fink et al., 2007 (72) LACE Reduced recurrence with daidzein in postmenopausal women treated with tamoxifen Guha et al., 2009 (73) JPHC No association with plasma levels of tea catechins Iwasaki et al., 2010 (75) SWHS Reduced risk with higher urinary levels of epicatechin Luo et al., 2010 (76) SBCSS Reduced mortality and recurrence with soy foods intake Shu et al., 2009 (137) NHS No association with intake of flavonols Adebamowo et al., 2005 (166) African American No association between intake of tea and coffee and cancer risk Boggs et al., (2010) (104) Lung Finland Reduced risk with increased intake of flavanols and flavan-3-ols in men smokers Mursu et al., 2008 (83) IWHS Reduced lung cancer with increased intake of flavanones and proanthocyanidins in current and past smokers Cutler et al., 2008 (84) "
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    ABSTRACT: The objective of this work is to review data from epidemiological and preclinical studies addressing the potential benefits of diets based on flavonoids for cancer prevention. Flavonoids are subdivided into subclasses including flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones. Epidemiological studies suggest dietary intake of flavonoids may reduce the risk of tumors of the breast, colon, lung, prostate, and pancreas. However, some studies have reported inconclusive or even harmful associations. A major challenge in the interpretation of epidemiological studies is that most of the data originate from case-control studies and retrospective acquisition of flavonoid intake. Differences in agricultural, sociodemographics, and lifestyle factors contribute to the heterogeneity in the intake of flavonoids among populations residing in the United States, Europe, and Asia. Dose and timing of exposure may influence the anticancer response to flavonoid-rich diets. A limited number of intervention trials of flavonoids have documented cancer preventative effects. Proposed anticancer mechanisms for flavonoids are inhibition of proliferation, inflammation, invasion, metastasis, and activation of apoptosis. Prospective studies with larger sample sizes are needed to develop biomarkers of flavonoid intake and effect. Mechanistic studies are needed to ascertain how flavonoid-rich diets influence gene regulation for cancer prevention.
    Journal of Nutrition in Gerontology and Geriatrics 07/2012; 31(3):206-38. DOI:10.1080/21551197.2012.702534
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    • "Subsequently, we tested the antiproliferative effect of these extracts using the breast cancer cell line MCF-7. The interest in using a breast cancer cell line as an experimental system to test the potential anticancer properties of these extracts relies on data from in vitro and epidemiological studies that relate the phytochemical groups, including carotenoids and phenolics, with breast cancer chemoprevention (Prakash et al. 2001; Sato et al. 2002; Brusselmans et al. 2005; Fink et al. 2007). "
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    ABSTRACT: We evaluated the antiproliferative effect of aqueous extracts of 14 plant foods consumed in Mexico on the breast cancer cell line MCF-7. The plant foods used were avocado, black sapote, guava, mango, prickly pear cactus stems (called nopal in Mexico, cooked and raw), papaya, pineapple, four different cultivars of prickly pear fruit, grapes and tomato. beta-Carotene, total phenolics and gallic acid contents and the antioxidant capacity, measured by the ferric reducing/antioxidant power and the 2,2-diphenyl-1,1-picrylhydrazyl radical scavenging assays, were analyzed in each aqueous extract. Only the papaya extract had a significant antiproliferative effect measured with the methylthiazolydiphenyl-tetrazolium bromide assay. We did not notice a relationship between the total phenolic content and the antioxidant capacity with antiproliferative effect. It is suggested that each extract of plant food has a unique combination of the quantity and quality of phytochemicals that could determine its biological activity. Besides, papaya represents a very interesting fruit to explore its antineoplastic activities.
    International Journal of Food Sciences and Nutrition 06/2009; 60(s6):1-15. DOI:10.1080/09637480802312922 · 1.21 Impact Factor
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    • "The flavanones hesperetin and eriodictyol are present in high amounts in citrus fruits such as orange, lemon, lime, and grapefruit (Kim et al. 2001; Scholz et al. 2006). These flavonoids have been reported potentially to prevent certain diseases such as coronary heart disease, stroke, and cancer (Fisher et al. 2003; Fink et al. 2007). "
    C Huang · Y Chen · T Zhou · G Chen ·
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    ABSTRACT: Dietary flavonoids catechin, epicatechin, eriodictyol, and hesperetin were investigated as substrates and inhibitors of human sulfotransferases (hSULTs). Purified recombinant proteins and human intestine cytosol were used as enzyme sources. hSULT1A1 and hSULT1A3 as well as human intestine cytosol can catalyse the sulfation of the investigated flavonoids. Sulfation of catechin, epicatechin, eriodictyol, and hesperetin by recombinant hSULTs showed substrate inhibition at high flavonoid concentrations. Hesperetin and eriodictyol are potent inhibitors of purified hSULT1A1, hSULT1A3, hSULT1E1, and hSULT2A1. Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1. The sulfation efficacy and potency of inhibition is related to the C-ring structure of flavonoids. These results suggest that dietary flavonoids may regulate human SULT activity and, therefore, affect the regulation of hormones and neurotransmitters, detoxification of drugs, and the bioactivation of pro- carcinogens and pro-mutagens.
    Xenobiotica 05/2009; 39(4):312-22. DOI:10.1080/00498250802714915 · 2.20 Impact Factor
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