The renaissance of insulin pump treatment in childhood type 1 diabetes.
ABSTRACT Current goals for the treatment of children and adolescents with type 1 diabetes mellitus include achieving near-normal blood sugar levels, minimizing the risk of hypoglycemia, optimizing quality of life, and preventing or delaying long-term microvascular and macrovascular complications. Continuous subcutaneous insulin infusion (CSII), or insulin pump therapy, provides a treatment option that can assist in the attainment of all of these goals in all ages of children. In pediatric patients, CSII has been demonstrated to reduce both glycosylated hemoglobin levels and frequency of severe hypoglycemia, without sacrifices in safety, quality of life, or weight gain, particularly in conjunction with the use of new insulin analogs and improvements in pump technology. Clinical studies of safety and efficacy of CSII in children are reviewed, as well as criteria for patient selection and practical considerations using pump therapy in youth with T1DM.
- SourceAvailable from: Valentina Petkova[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study is to assess long-term metabolic outcomes in children with diabetes mellitus and to compare the efficacy, feasibility and metabolic control expenses for treatment with continuous subcutaneous insulin infusion (CSII), compared to human insulin treatment. The study sample included 34 children aged 3 to 18 years with type 1 diabetes, 17 with continuous subcutaneous insulin infusion (CSII) therapy and 17 with standard treatment with human insulin. The study observed for the following variables: duration of the disease, diabetic control, HbA1c deviation scores; height and weight deviation and price of the treatment. Methods applied include meta-analyses in the published medical lit-erature, pharmacoeconomic analysis and statistical analysis. From the 34 children with diabetes type 1 observed retro-spectively during the period 1999-2012, 17 were on CSII (mean age 10 years, mean duration of the disease—7 years, average usage of CSII—3 years). The test stripes cost 533 Euro/year (1100 stripes per year) and their average cost ac-cording to the duration of the disease is 3779.45 Euro since diagnosis. The blood glucose monitoring system costs 20 Euro and for the duration of the disease—4.96 Euro per patient per year. The average improvement of HbA(1c) after the CSII introduction is 1.85, while after the application of human insulin—0.28. The treatment with CSII leads to signifi-cant improvement in glycemic control compared to the treatment with human insulin. The reduced HbA(1c) shows good diabetes management, from one point of view, and good quality of life—from another.Modern Economy 01/2013; 4(10):9-13. DOI:10.4236/me.2013.410A002
- [Show abstract] [Hide abstract]
ABSTRACT: Insulin pump therapy is a commonly used alternative to multiple daily injections (MDI) in the treatment of pediatric type 1 diabetes. The aim of the current study was to examine whether there are different medical and psychosocial outcomes for adolescents using MDI versus pump therapy as experienced in a naturally occurring context of self- or doctor-chosen insulin regimens. Adolescents and their parents completed questionnaires assessing quality of life and parenting stress. A1C levels were obtained from the medical record. Metabolic and psychosocial outcomes did not differ significantly between adolescents using pump therapy and adolescents using MDI. Higher parental stress was associated with older children, lower quality of life, and higher A1C levels. Physicians might present this information to families along with the potential advantages and disadvantages of pumps and injections.Diabetes research and clinical practice 08/2010; 89(2):121-5. DOI:10.1016/j.diabres.2010.04.010 · 2.54 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: In the treatment of childhood type 1 diabetes, being aware of the parents' fear of hypoglycemia is important, since the parents' fear may influence the management of treatment and the children's blood glucose regulation. The availability of proper instruments to assess the parents' fear of hypoglycemia is essential. Thus, the aim of this study was to examine the psychometric properties of the Hypoglycemia Fear Survey - Parent version (HFS-P). In a Norwegian population-based sample, 176 parents representing 102 children with type 1 diabetes (6-15 years old) completed the HFS-P, comprising a 15-item worry subscale and a 10-item behavior subscale. We performed exploratory and confirmatory factor analysis and further analysis of the scales' construct validity, content validity and reliability. The Norwegian version of the HFS-P had an acceptable factor structure and internal consistency for the worry subscale, whereas the structure and internal consistency of the behavior subscale was more questionable. The HFS-P subscales were significantly correlated (from moderately to weakly) with symptoms of emotional distress, as measured by the Hopkins Symptom Checklist - 25 items. The mothers scored higher than fathers on both HFS-P subscales, but the difference was not statistically significant for the worry subscale. The HFS-P worry subscale seems to be a valid scale for measuring anxiety-provoking aspects of hypoglycemia, and the validity of the HFS-P behavior subscale needs to be investigated further.BMC Endocrine Disorders 01/2015; 15(1):2. DOI:10.1186/1472-6823-15-2 · 1.67 Impact Factor