Dynamics of postsynaptic glutamate receptor targeting

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.
Current Opinion in Neurobiology (Impact Factor: 6.63). 03/2007; 17(1):53-8. DOI: 10.1016/j.conb.2006.11.001
Source: PubMed


Targeting of glutamate receptors to synapses is an important event in both developing and mature neurons. Glutamate receptors are delivered to nascent synapses during synaptogenesis and to existing synapses during activity-dependent synaptic strengthening. Increasing evidence suggests that glutamate receptors are inserted into the plasma membrane before they accumulate at the synapse. Lateral diffusion of receptors occurs at both synaptic and non-synaptic membranes, and glutamate receptors can exchange rapidly between synaptic and extrasynaptic sites. In addition, recent studies show that postsynaptic scaffold molecules can be highly mobile. The dynamic nature of the synapse suggests that many mechanisms might be involved in regulating synapse formation and synaptic plasticity.

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    • "These changes include the formation of new spines (Engert and Bonhoeffer, 1999; Maletic-Savatic et al., 1999; Toni et al., 1999) and increases in the number of glutamatergic AMPA receptors in the dendritic spines (Isaac et al., 1995; Liao et al., 1995; Durand et al., 1996). The rapid increase in synapse area after LTP inducing stimulation results in changes in synapse shape and receptor availability, thus augmenting neurotransmission (Chen et al., 2007). Likewise, hippocampal-dependent learning is associated with similar synaptic rearrangements (Leuner et al., 2003; Knafo et al., 2004) as well as AMPA receptor trafficking into synapses in CA1 (Hu et al., 2007). "
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    Frontiers in Molecular Neuroscience 02/2010; 3:1. DOI:10.3389/neuro.02.001.2010 · 4.08 Impact Factor
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    • "A number of AMPA receptor interacting proteins are important for AMPA receptor trafficking during synaptic plasticity [reviewed in (Barry and Ziff, 2002; Bredt and Nicoll, 2003; Chen et al., 2006; Malenka, 2003; Nicoll et al., 2006; Sheng and Hyoung Lee, 2003)]. "
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    Neuron 01/2010; 65(1):80-93. DOI:10.1016/j.neuron.2009.12.021 · 15.05 Impact Factor
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    • "On an intermediate time scale, reversible changes in ILD sensitivity in the gerbil's brainstem lasting several days can be induced by noise exposure (Siveke et al. 2007), which may cause homeostatic adaptation to the overall driving force or changes in the turnover and trafficking of receptors, vesicles, and proteins in the postsynaptic machinery (reviews: Bruneau et al. 2006, Chen et al. 2007). Such explanations only occur over the time course of several hours and are therefore unlikely mechanisms underlying the plasticity observed in this study. "
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