Intakes of Fruits, Vegetables, Vitamins A, C, and E, and Carotenoids and Risk of Renal Cell Cancer

Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Cancer Epidemiology Biomarkers & Prevention (Impact Factor: 4.13). 01/2007; 15(12):2445-52. DOI: 10.1158/1055-9965.EPI-06-0553
Source: PubMed


Fruits and vegetables rich in antioxidants have been proposed to reduce the risk of renal cell cancer. However, few prospective studies have examined the intakes of fruits, vegetables, and antioxidant vitamins in relation to the risk of renal cell cancer.
We prospectively examined the associations between the intakes of fruits, vegetables, vitamins A, C, and E, and carotenoids and risk of renal cell cancer in women and men. We followed 88,759 women in the Nurses' Health Study from 1980 to 2000, and 47,828 men in the Health Professionals Follow-up Study from 1986 to 2000. We assessed dietary intake every 2 to 4 years using a validated semiquantitative food frequency questionnaire. The Cox proportional hazards model was used to estimate study-specific multivariate relative risks (RR), which were pooled using a random effects model.
A total of 248 (132 women and 116 men) incident renal cell cancer cases were ascertained during 2,316,525 person-years of follow-up. The consumption of fruits and vegetables was associated with a decreased risk of renal cell cancer in men (multivariate RR, 0.45; 95% CI, 0.25-0.81, for >or=6 servings of fruit and vegetable intake/d versus <3 servings/d; P test for trend = 0.02), but not in women (multivariate RR, 1.17; 95% CI, 0.66-2.07, for the same contrast; P test for trend = 0.25; P test for between-studies heterogeneity = 0.02). Intakes of vitamins A and C from food and carotenoids were inversely associated with the risk of renal cell cancer in men only, but we cannot exclude the possibility that this was due to other factors in fruit and vegetables. No clear association was observed for vitamin E in women or men.
Fruit and vegetable consumption may reduce the risk of renal cell cancer in men.

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    British Journal of Cancer 09/2011; 105(7):1096-104. DOI:10.1038/bjc.2011.343 · 4.84 Impact Factor
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    • " association between fruit and vegetable intake and kidney cancer , although we cannot exclude a weak protective effect . Previous cohort studies found significant or non - significant inverse associations between fruit and / or vegetable intake and kidney cancer risk ( Fraser et al . , 1990 ; Rashidkhani et al . , 2005 ; van Dijk et al . , 2005 ; Lee et al . , 2006 ; George et al . , 2009 ) , while another study reported no association ( Weikert et al . , 2006 ) . There was an inverse association between fruit and vegetable intake and risk of all cancer sites combined , although again was the association stronger for fruit than for vegetables . It should be noted that our estimate for all sites co"
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    • "A balanced diet has been shown to promote overall well-being and health (USDA, 2000). Dietary patterns with higher fruit and vegetable (F&V) intake are associated with treating and preventing metabolic syndrome (Feldeisen and Tucker, 2007) and promoting a variety of health benefits; including decreased risk for certain cancers (Lee et al., 2006), reduced morbidity and mortality from heart disease (Feldeisen and Tucker, 2007), enhanced diabetes prevention (Hodge et al., 2007) and improved weight management (Bazzano, 2006). "
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