Low-grade adenosquamous carcinoma (LGAC), a rare variant of metaplastic breast cancer, may mimic benign or other low-grade malignant lesions histologically. Diagnostic difficulty may be encountered when evaluating breast cytology, core needle biopsy or intraoperative frozen section specimens.
Pathology reports, cytology aspirates and histological slides of LGAC diagnosed at the Department of Pathology, Singapore General Hospital, were reviewed. Four cases of LGAC were analysed. Cytology from the first case showed atypical cells and the subsequent surgical excision specimen showed a complex sclerosing lesion with LGAC. The second and third cases were investigated by core needle biopsies: the preoperative histological features were suggestive of but not diagnostic of LGAC, until further excision biopsies were performed. The fourth case entailed a frozen section specimen, for which definitive diagnosis was deferred to paraffins. The patients remained well with no evidence of recurrent disease to date.
When limited material, in the form of needle aspirates, core biopsy specimens or frozen sections, is submitted for histology, making a diagnosis of LGAC is not only challenging, but may be impossible. In difficult cases, careful pathological assessment, clinicopathological correlation and follow-up or complete excision biopsy may prove invaluable in establishing a definitive diagnosis.
"At core biopsy the overall architecture is not appreciable, and intraoperative frozen section is limited due to sampling  ; therefore, preoperative confirmation is rare, as seen in the biopsy from the left breast in our case. Nuclear uniformity/enlargement, monomorphism , keratin debris, and the presence of metaplastic squamous cells may reduce false negative rates on FNAC  . Immunomarkers such as p63 may aid in recognizing the squamous elements that facilitate exact tumor typing; however, this requires a high preoperative index of suspicion . "
Available from: Adriano Oliveira Torres de Carrasco
"Apesar da alta incidência de tumores de mama em mulheres , o tipo histológico de carcinoma adenoescamoso é raro. O carcinoma adenoescamoso de mama em geral é caracterizado por ser bem circunscrito, integrante do grupo dos carcinomas metaplásicos, associados à mutação do antioncogene BRCA1 e ao bom prognóstico (Ho et al 2006, Geyer et al. 2010, Noël et al. 2010). Independente do tipo histológico, tanto em mulheres como em outros animais como cadelas, gatas e possivelmente em primatas não humanos , o tratamento para as neoplasias malignas de mama deve ser realizado de forma precoce para a obtenção de melhor prognóstico (Gomes 1997, Lana et al. 2007, Morris & Dobson 2007). "
[Show abstract][Hide abstract] ABSTRACT: Mammary tumors in non-human primates are rare. The aim of this paper is to report the occurrence and treatment outcomes of a female Cebus sp. (fam. Cebidae) with high-grade mammary carcinoma received at the Serviço de Atendimento de Animais Selvagens (SAAS), Universidade Estadual do Centro-Oeste. A right mammary gland nodule was identified and at radiographic examination a point of radiopacity due to gun projectile entrapped within the mammary mass was seen. After the patient stabilization, the mass was excised and submitted to histopathological examination. The diagnosis was of high-grade carcinoma, compatible with adenosquamous carcinoma. The monkey was transported to Wild Animals Treat and Receiving Center (CETAS) and introduced into a colony. More than 20 months after surgery no evidence of relapse was seen and the patient is living with the group. That suggests that the adopted therapy was effective, achieving quality of life and increased survival.
"However, due to the inherent limitations of the core biopsy, diagnostic excision was recommended by the histopathologist. Ho et al  have demonstrated in their small series of four cases that limited material in fine needle aspiration/core biopsy does not yield enough material for confirmatory histopathological diagnosis. "
[Show abstract][Hide abstract] ABSTRACT: Adenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma. We report such a case in a 19 years old female.
Case notes and histopathology were reviewed. Adenosquamous carcinoma was diagnosed on wide local excision and patient underwent skin-sparing mastectomy with Latissimus dorsi flap reconstruction.
Adenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma. Data on correct management, follow-up and prognosis are very limited but given the high potential for local recurrence, aggressive surgery may be the only option.
World Journal of Surgical Oncology 05/2010; 8(1):44. DOI:10.1186/1477-7819-8-44 · 1.41 Impact Factor
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