Gonorrhoea and male bladder cancer in a prospective study

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
British Journal of Cancer (Impact Factor: 4.84). 02/2007; 96(1):169-71. DOI: 10.1038/sj.bjc.6603510
Source: PubMed


In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis.

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    • "Although the majority of bladder tumors formed due to Schistosoma infection are squamous cell carcinomas (SCC), adenocarcinomas and transitional cell carcinomas (TCC) or undifferentiated carcinomas can develop (Johansson & Cohen, 1997 ) Furthermore, it appears that there is a proportional increase of TCC due to schistosomal infections over time (Koraitim et al.,1995). Some researchers believe that TCC need more time to progress than SCC and are closely related with a less devastating inflammatory infiltrate (Michaud et al., 2007). "
    Schistosomiasis, 01/2012; , ISBN: 978-953-307-852-6
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    ABSTRACT: We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a population-based case-control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46-0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18-0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.
    British Journal of Cancer 02/2009; 100(5):834-9. DOI:10.1038/sj.bjc.6604889 · 4.84 Impact Factor
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    ABSTRACT: Several epidemiologic studies have investigated sexually transmitted infections (STIs) and later risk of genitourinary conditions with suggestive positive results. While these results may reflect causal associations, other possible explanations include confounding by factors possibly related to both STI acquisition and genitourinary condition risk such as recognized STI-risk factors/correlates, and other factors not typically considered in relation to STIs (e.g., general health-related behaviors or markers of such behaviors). Very few of these factors have been investigated in older populations in which STIs and genitourinary conditions are typically studied. Therefore, we investigated STI history correlates in one such population, the Health Professionals Follow-up Study. We ascertained histories of potential correlates, gonorrhea, syphilis by questionnaire (n = 36,032), and performed serologic testing for Chlamydia trachomatis, Trichomonas vaginalis, human papillomavirus, and human herpesvirus type 8 infection in a subset (n = 651). Positive correlations were observed for African-American race, foreign birth, southern residence, smoking, alcohol consumption, ejaculation frequency, vasectomy, and high cholesterol. Inverse correlations were observed for social integration and routine health-related examinations. These findings provide useful information on potential confounders for epidemiologic investigations of STIs and chronic diseases, and interesting new hypotheses for STI prevention (e.g., STI counseling before vasectomy).
    Cancer Causes and Control 09/2009; 20(9):1623-34. DOI:10.1007/s10552-009-9409-9 · 2.74 Impact Factor
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