Neuropsychological profiles of patients with obsessive-compulsive disorder: Early onset versus late onset

Clinical Research Center, Seoul National University Hospital, Seoul, South Korea.
Journal of the International Neuropsychological Society (Impact Factor: 2.96). 02/2007; 13(1):30-7. DOI: 10.1017/S1355617707070063
Source: PubMed


In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Complex Figure Test (RCFT) and the letter and category fluency of the Controlled Oral Word Association Test (COWA), compared to the normal controls and the early-onset OCD patients. The controls and early-onset OCD patients did not differ on any of the neuropsychological measurements taken in this study. These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD.

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    • "However, findings of cognitive dysfunction in OCD have not been consistent across studies (Kuelz et al. 2004; Chamberlain et al. 2005). Discrepant findings may be attributable to confounding factors including sex (Savage et al. 2000; Deckersbach et al. 2004), duration of illness (Nakao et al. 2009), medication status (Nakao et al. 2009; Segalas et al. 2010), comorbidity (Aycicegi et al. 2003), age at onset of illness (Henin et al. 2001; Roth et al. 2005; Hwang et al. 2007), insight (Tumkaya et al. 2009), family history (Boone et al. 1991) and symptom-based subtype (Ceschi et al. 2003; Cha et al. 2008; Nedeljkovic et al. 2009). However, data on the impact of these confounding factors on cognitive functioning have been conflicting. "
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