Article

Synthesis, in vitro and in silico evaluation of l-tyrosine containing PPARalpha/gamma dual agonists.

Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, India.
Bioorganic & Medicinal Chemistry (impact factor: 2.92). 03/2007; 15(3):1547-55. DOI:10.1016/j.bmc.2006.06.063 pp.1547-55
Source: PubMed

ABSTRACT A novel series of l-tyrosine derivatives have been reported with potential PPARalpha/gamma dual agonistic activity. In vitro cell based PPARalpha/gamma transactivation studies have shown compound 4a and compound 4f to be the most potent PPARgamma and PPARalpha activators, respectively. Molecular docking studies performed on these series of compounds have complemented the experimental results and have led to interesting inferences.

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Keywords

compound 4a
 
compound 4f
 
compounds
 
interesting inferences
 
novel series
 
potential PPARalpha/gamma dual agonistic activity
 
PPARalpha activators
 
PPARalpha/gamma transactivation studies
 
vitro cell