Possibility of membrane modification as a mechanism of antimony resistance in Leishmania donovani.

Hema Kothari, Pranav Kumar, Shyam Sundar, Neeloo Singh

Drug Target Discovery and Development Division, Central Drug Research Institute, Lucknow, India.

Journal Article: Parasitology International (impact factor: 1.78). 04/2007; 56(1):77-80. DOI: 10.1016/j.parint.2006.10.005

Abstract

Resistance to antimonials has become a clinical threat in the treatment of visceral leishmaniasis (VL). Unravelling the resistance mechanism needs attention to circumvent the problem of drug resistance. In one of the resistant isolates, we earlier identified a gene (PG1) implicated in antimony resistance whose localization in the present study was confirmed on the pellicular plasma membrane of the parasite thereby indicating towards membrane modification as a mechanism of resistance in this resistant isolate.

Source: PubMed

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Keywords

antimony resistance
 
circumvent
 
clinical threat
 
drug resistance
 
membrane modification
 
pellicular plasma membrane
 
resistance mechanism
 
visceral leishmaniasis