Article

No association between dinucleotide repeat polymorphism in intron 1 of the epidermal growth factor receptor gene EGFR and risk of lung cancer.

Cancer Research Institute, Kyungpook National University Hospital, Samduk 2Ga 50, Daegu, 700-412, Korea.
Cancer Genetics and Cytogenetics (impact factor: 1.39). 02/2007; 172(1):29-32. DOI:10.1016/j.cancergencyto.2006.07.012 pp.29-32
Source: PubMed

ABSTRACT The tyrosine kinase receptor EGFR pathway is one of the oncogenic signaling cascades involved in lung cancer, mediating the epidermal growth factor receptor gene EGFR. First-intron polymorphisms with greater numbers of CA dinucleotide repeats tend to downregulate EGFR expression, which suggests that this polymorphism may modulate susceptibility to lung cancer. The present hospital-based case-control study evaluated the possible association of CA repeat polymorphism in the EGFR gene with risk of lung cancer in a Korean population. A bimodal pattern appeared, with a frequency of 57.1% for 20 CA repeats and 18.6% for 16 CA repeats. There was, however, no significant difference in distribution of allele genotypes between all lung cancer cases and the controls, nor among histological types for the cases.

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Keywords

epidermal growth factor receptor gene EGFR
 
First-intron polymorphisms
 
greater numbers
 
histological types
 
Korean population
 
lung cancer
 
lung cancer cases
 
oncogenic signaling cascades
 
polymorphism
 
possible association
 
present hospital-based case-control study
 
repeat polymorphism
 
tyrosine kinase receptor EGFR pathway