Article

The association between body size, prostate volume and prostate-specific antigen.

Vanderbilt Epidemiology Center, Division of Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA.
Prostate Cancer and Prostatic Diseases (impact factor: 2.42). 02/2007; 10(2):137-42. DOI:10.1038/sj.pcan.4500924 pp.137-42
Source: PubMed

ABSTRACT Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume, prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume..

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Keywords

associations
 
BMI
 
consistent
 
high-grade prostatic intraepithelial neoplasia
 
Increasing prostate volume contributes
 
lowest
 
men
 
obesity
 
prostate biopsy
 
prostate volume
 
prostate-specific antigen
 
waist-to-hip ratio