Primary Rhabdomyosarcoma of the Breast in a 13-Year-Old Girl: Report of a Case

Department of Breast and Endocrine Surgery, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Tokyo 105-8461, Japan.
Surgery Today (Impact Factor: 1.53). 02/2007; 37(1):38-42. DOI: 10.1007/s00595-006-3326-2
Source: PubMed


We report a case of primary alveolar rhabdomyosarcoma of the breast in a 13-year-old Japanese girl. The patient initially presented with a 13 x 8-cm mass in her left breast, which was diagnosed as alveolar rhabdomyosarcoma after an excisional biopsy. Genetic expression of the tumor revealed t(2;13)(q35-37;q14). She underwent modified radical mastectomy (Bt + Ax) and nine lymph nodes were found to be involved. Systemic examinations showed multiple bone and lung metastases 2 weeks after her operation. Despite chemotherapy with doxorubicin, ifosfamide, and actinomycin D, which resulted in remission for 6 months, she died of the disease 8 months after surgery.

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