Leptin, superoxide dismutase, and weight loss: initial leptin predicts weight loss.
ABSTRACT Our goal was to study how plasma leptin concentration, superoxide dismutase (SOD) activity, and weight loss are related in obese adults.
Serum leptin concentration, SOD activities, general biochemical data, and body composition measurements were obtained for 62 overweight and obese subjects before and after an 8-week body weight reduction (BWR) regimen. The subjects were on dietary control, performed moderate aerobic and strength training exercises, and attended educational lectures.
The measurement results indicated that the following criteria were significantly reduced: body weight [84.4 +/- 17.0 vs. 79.3 +/- 16.1 (standard error) kg, p < 0.001]; BMI (31.5 +/- 4.3 vs. 29.4 +/- 4.2 kg/m(2), p < 0.001), and fat mass (33.3 +/- 10.0 vs. 29.8 +/- 10.4 kg, p < 0.001). Plasma leptin levels also significantly decreased from 31.5 +/- 17.6 to 26.5 +/- 17.2 ng/mL (p < 0.001). Additionally, SOD activity was significantly increased from 261.4 +/- 66.0 to 302.7 +/- 30.9 U/mL (p < 0.001). Based on linear regression analysis results, a 3.78- to 8.13-kg reduction in weight can be expected after the 8-week BWR regimen when initial leptin concentration was 5 to 30 ng/mL.
We found that an 8-week exercise and diet program was effective in reducing weight and fat mass and, notably, had further beneficial effects on leptin resistance and SOD activity. Additionally, this study demonstrated that initial plasma leptin concentration may be used as a predictor for weight loss outcome.
Article: Internet-delivered lifestyle physical activity intervention: limited inflammation and antioxidant capacity efficacy in overweight adults.[show abstract] [hide abstract]
ABSTRACT: Overweight and physical inactivity are associated with elevated reactive oxygen species and chronic low-grade inflammation. Exercise training studies have measured changes in systemic inflammatory and oxidative/antioxidative biomarkers but predominantly at moderate-high intensities. Few low-intensity, lifestyle-based physical activity (PA) studies have been conducted. The purpose of this study was to determine whether improvements in lifestyle-oriented PA resulting from a 16-wk Internet-delivered PA program [Active Living Every Day-Internet (ALED-I)] elicit cardioprotective improvements in measures of inflammation, oxidation, or antioxidant enzyme capacity. Forty-one men and women (age 23-62 yr) were randomized to either the ALED-I intervention [n = 19; age = 40.4 +/- 1.9 yr; body mass index (BMI) = 31.4 +/- 1.1 kg/m(2)] or a delayed intent-to-treat control condition (n = 22; age = 46.6 +/- 1.3 yr; BMI = 31.0 +/- 0.7 kg/m(2)). TNF-alpha, C-reactive protein, myeloperoxidase, superoxide dismutase, catalase, total antioxidative capacity, change in PA, and other cardiometabolic disease risk factors were measured at baseline and postintervention. The ALED-I group increased PA and decreased central adiposity without changes in the control group. There was no change in the control group for any inflammation, oxidation, or antioxidant biomarkers. TNF-alpha decreased (P = 0.01) in the intervention group but was not statistically different from the control group. In conclusion, modest improvements in daily low-intensity ambulatory PA as a result of an Internet-delivered lifestyle PA intervention may be cardioprotective in sedentary and overweight adults through reductions in central adiposity and inflammation. However, the absence of favorable changes in other inflammation, oxidation, and antioxidant biomarkers highlights the need for further attention to the dose response of lifestyle-structured PA promotion strategies for health maintenance/improvement.Journal of Applied Physiology 12/2008; 106(1):49-56. · 3.75 Impact Factor