Hemosiderotic Dermatofibroma: Report of One Case

Dermatology Section, Department of Systematic Pathology, Federico II University of Naples, Naples, Italy.
Dermatology (Impact Factor: 1.57). 02/2007; 214(1):82-4. DOI: 10.1159/000096918
Source: PubMed


Dermatofibroma (DF) is a common benign fibrohistiocytic lesion which presents with a wide variety of clinicopathological features. Generally, the clinical diagnosis is easy, but differentiating it from other cutaneous tumors could be difficult in atypical cases and rare variants. We may find at least four different histopathological variants of DF; more than one of which may be present in a single tumor. Hemosiderotic DF is a variant composed of numerous small vessels, extravasated erythrocytes, and intra- and extracellular hemosiderotic deposits. The differential diagnosis may comprise melanoma as well as other melanocytic and nonmelanocytic tumors. We report the case of a 38-year-old man who presented with a hemosiderotic DF on the abdomen.

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    • "The histopathological features of several variants may also coexist in the same lesion and may correspond to different stages of the same disease. Some authors consider hemosiderotic DF a precursor lesion in the development of aneurysmal DF [9, 10]. Our case, illustrating a giant hemosiderotic DF, is in agreement with this theory. "
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    ABSTRACT: Dermatofibroma is a common benign fibrohistiocytic lesion that usually appears as a slow-growing, firm dermal nodule with a predilection for the legs of middle-aged women. They are usually smaller than 2 cm in diameter. Many histological variants have been described. Generally, the clinical and histological diagnosis is straightforward, but differentiating it from other cutaneous tumors can be difficult in atypical cases and rare variants. Giant dermatofibroma is a rare clinical variant of dermatofibroma and less than 25 cases have been reported. It is characterized essentially by its unusually large size, which often mimics malignant tumors clinically. We first present the case of a giant hemosiderotic dermatofibroma in a 54-year-old patient, who presented with a large ulcerated mass of the left foot which was excised, and then review the literature briefly.
    Case Reports in Dermatology 02/2011; 3(1):32-6. DOI:10.1159/000324721

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