Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy.

Neurology Department, EMG/ENG Laboratory, University of Patras Medical School, 26504, Rion-Patras, Greece.
Neurology (Impact Factor: 8.3). 01/2007; 67(12):2253-5. DOI: 10.1212/01.wnl.0000249344.99671.d4
Source: PubMed

ABSTRACT We conducted a randomized, open-label, controlled trial to assess the efficacy of oxcarbazepine for prophylaxis against oxaliplatin-induced peripheral neuropathy (OxIN). Thirty-two patients with colon cancer received 12 courses of the FOLFOX-4 regimen and were randomly assigned to receive oxcarbazepine (600 mg BID) or chemotherapy without oxcarbazepine. The incidence of OxIN was strikingly decreased in patients receiving oxcarbazepine (31.2% vs 75%). Oxcarbazepine may prevent OxIN symptoms. Further larger placebo-controlled trials are warranted to confirm our results.

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