Article

Stent fracture associated with drug-eluting stents: clinical characteristics and implications.

Division of Cardiology, School of Medicine, University of California-Los Angeles, UCLA Medical Center, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Catheterization and Cardiovascular Interventions (impact factor: 2.29). 03/2007; 69(3):387-94. DOI:10.1002/ccd.20942 pp.387-94
Source: PubMed

ABSTRACT To evaluate the clinical characteristics and implications of stent fracture in drug-eluting stents.
Approximately 2.5 million drug-eluting stents are implanted every year worldwide. In 10 randomized controlled trials involving 2,602 patients, no incidence of stent fracture was recognized or reported.
From April 2003 to December 2005, 2,728 patients underwent drug-eluting stenting. The angiograms of all 530 patients who underwent repeat angiography were analyzed to identify the presence of stent fracture. We then documented the incidence of adverse events associated with drug-eluting stent fracture and systematically analyzed the clinical, procedural, and structural factors, which might predispose to stent fracture.
Stent fracture was identified in 10 patients. None of these fractures were detectable at the time of stent placement. The median time interval from stent implantation to detection of fracture at repeat angiography was 226 days (range, 7-620 days). Adverse clinical outcomes associated with stent fracture occurred in 7 patients (6 patients had binary restenosis and 1 patient had stent thrombosis), all necessitating repeat intervention. Analysis of potential predisposing clinical, procedural, and structural factors revealed that 4 patients had excessive tortuosity in the proximal segment, and overlapping stents were used in 5 cases. All fractures occurred in sirolimus-eluting stents.
Stent fracture may represent a new potential mechanism of restenosis and stent thrombosis in drug-eluting stents. Predisposing clinical and procedural factors may be vessel tortuosity and use of overlapping stents. The most important predisposing factor, however, may be stent structure, since all fractures occurred in sirolimus-eluting stents.

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Keywords

10 patients
 
2.5 million drug-eluting stents
 
4 patients
 
5 cases
 
6 patients
 
7 patients
 
Adverse clinical outcomes
 
clinical characteristics
 
drug-eluting stent fracture
 
drug-eluting stents
 
new potential mechanism
 
overlapping stents
 
potential predisposing clinical
 
Predisposing clinical
 
predisposing factor
 
proximal segment
 
repeat angiography
 
repeat intervention
 
sirolimus-eluting stents
 
stent placement
 

Michael S Lee