A 62-year-old male Turkish patient had a pigmented lesion on the sole with a 10-year history. It was an asymmetrical macular lesion with an irregular border and irregular brown pigmentation and had a diameter of 1.2 cm x 1.7 cm. Dermoscopy revealed a parallel ridge pattern and an abrupt cut-off of pigmentation on the upper edge. Histologically lentiginous hyperplasia decorated by innocent melanocytes and scattered melanocytic proliferation with slight to moderate cytological atypia were seen. Atypical melanocytes were very scattered and it was insufficient to call it a melanoma in situ. A second finding was a microvascular proliferation located in the papillary dermis. There was no sign of regression such as fibrous tissue or host reaction. Atypical melanosis of the foot has rarely been reported in the published work, which are from Japan and Korea. This case is presented to emphasize the significance of this rare entity which has recently been reported to be a very early phase of acral melanoma.
"Yamaura and colleagues have indicated that dermoscopic observations may be superior to histopathologic methods for the detection of early lesions of acral melanoma owing to the specificity of the parallel ridge pattern during detection of acral melanoma in the histopathologically unrecognizable early-development phase13. Recently, in another interesting report by Kilinc Karaarslan et al., dermoscopic features of the parallel ridge pattern were also shown in AMOF14. These findings support the suggestion that dermoscopic findings can be more critical in a histopathologically incredible early phase of malignancy. "
[Show abstract][Hide abstract] ABSTRACT: Clinical guidelines suggest that suspicious pigmented lesions of the plantar or palmar area require biopsy for early detection of acral melanoma. We present here a case of acral lentiginous melanoma in which various melanocytic atypia was observed at each biopsy site, including focal melanocytic proliferation. We suggest that this atypical melanosis is part of a contiguous phase of invasive tumor growth, which is known as the very early stage of melanoma in situ. In addition, noninvasive dermoscopy has been effective for the early discovery of hidden lesions of acral melanoma.
Annals of Dermatology 08/2011; 23(3):400-4. DOI:10.5021/ad.2011.23.3.400 · 1.39 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Acral lentiginous melanoma of the foot is a relatively rare but often very aggressive variant of melanoma. More commonly identified in patients with darker skin, diagnosis of the lesions is often delayed because the area is not routinely examined by patients or primary care physicians. In addition, these lesions often mimic other entities, including vascular lesions and infections. Greater awareness of this entity and performing appropriate biopsies will result in more timely diagnoses and improved survival.
Clinics in dermatology 11/2009; 27(6):556-63. DOI:10.1016/j.clindermatol.2008.09.014 · 2.47 Impact Factor
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