Monosomy 7 as the sole abnormality of an acute basophilic leukemia

Department of Laboratory Medicine, Chungnam National University Hospital, Daejeon, South Korea.
Cancer Genetics and Cytogenetics (Impact Factor: 1.93). 02/2007; 172(2):168-71. DOI: 10.1016/j.cancergencyto.2006.09.016
Source: PubMed


We report the case of a 72-year-old man who had the very rare disease acute basophilic leukemia with the sole chromosomal finding of a monosomy 7. Most nuclear cells in the peripheral blood and bone marrow samples were either basophils or blasts. The blasts showed negative reaction with myeloperoxidase, periodic acid Schiff, chloroacetate esterase, alpha-naphthyl butyrate esterase, acid phosphatase, and Sudan black B. Metachromatic features of the blasts, however, were observed with toluidine blue stain. Electron microscopic evaluation showed the typical ultrastructure, with basophil and immature mast cell granules. Cytogenetic study revealed monosomy 7 in all metaphase cells, and this finding was confirmed by fluorescence in situ hybridization. The Philadelphia chromosome was absent. Review of the literature revealed abnormalities in cases of ABL. To our knowledge, the case reported here is the first to have basophilic leukemia with monosomy 7 as the only chromosome abnormality.

20 Reads
  • Source
    • "A mechanism of the action has been recognized to some of these chromosomal alterations into of these transformations [1] [2]. Usually, only one primary chromosome change is present in the same leukemic clone [3] [4] [5] [6] [7]. But two or more chromosomal anomalies have been described in few reports, especially in basophilic leukemia (BL) [8]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22).
    09/2011; 2011:269491. DOI:10.1155/2011/269491
  • [Show abstract] [Hide abstract]
    ABSTRACT: Acute myeloid leukemia (AML) represents a group of hematopoietic neoplasms derived from the bone marrow precursors of myeloid lineage. The neoplastic process is the result of clonal proliferation of an aberrant, committed stem cell at the level of CFU-S or later stages of differentiation leading to the accumulation of immature forms without, or with limited, maturation. Other terms used to denote AML include acute nonlymphoid leukemia (ANLL), acute myelogenous leukemia, and acute myeloblastic leukemia. According to this classification, AML is divided into four major categories as: AML with recurrent genetic abnormalities, AML with multilineage dysplasia, AML and myelodysplastic syndromes (MDS), therapy related, AML not otherwise categorized. Three major environmental insults have been implicated in the increased incidence of AML: ionizing radiation, chemotherapeutic agents, and occupational exposure to chemicals. Ionizing radiation induces DNA damage leading to chromosomal breaks which may cause mutations, deletions, and translocations. The extent of this damage depends on the type of radiation, the amount and rate of absorption, distribution of the absorbed energy in the tissue, and the intervals between the radiation exposures. Therapy-related AML (t-AML) and therapy-related MDS (t-MDS) represent spectrums of a progressive clonal hematopoietic disorder that is evolved following cytotoxic chemotherapy and/or irradiation. The reason for chemotherapy or irradiation is usually a primary malignancy.
    Hematopathology, 01/2008: pages 207-255; , ISBN: 9780123706072
  • [Show abstract] [Hide abstract]
    ABSTRACT: Acute basophilic leukemia (ABL) is an uncommon form of acute myelogenous leukemia recently recognized as a distinct entity in the World Health Organization classification of myeloid malignancies. A case is presented of ABL arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). Discussion includes a literature review.
    Cancer Genetics and Cytogenetics 05/2008; 182(1):46-9. DOI:10.1016/j.cancergencyto.2007.12.009 · 1.93 Impact Factor
Show more