Gender Differences in Bipolar Disorder Type 1

Università di Pisa, Pisa, Tuscany, Italy
Journal of Nervous & Mental Disease (Impact Factor: 1.69). 02/2007; 195(1):93-6. DOI: 10.1097/01.nmd.0000243781.67035.b1
Source: PubMed


To explore gender differences in bipolar I disorder, we compared the longitudinal treatment outcome and baseline demographic and clinical characteristics of 27 male and 45 female adult subjects who were treated for an acute affective episode and longitudinally followed for a period of up to 48 weeks. Females were more likely to report a history of suicidal gestures and a comorbid panic disorder; males were more likely to present with a comorbid obsessive-compulsive disorder, and there was a trend for a more frequent history of alcohol or substance abuse. No significant differences were found between the genders for the time to remission from the index episode, number of recurrences, and time spent with any clinical or subclinical mood symptom during the 48 weeks of maintenance treatment. Although differences may exist between bipolar I male and female subjects, prospective course does not seem to reveal differences in a 48-week period, at least when similar treatment strategies are adopted.

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    • "Secondly, the social disintegration following a long career of what is often regarded as an antisocial behaviour by others creates difficulties in obtaining the kind of representative sample needed in order to generalize (Johnsson & Fridell, 1997). It is further difficult to determine the impact substance abuse as a single factor has on suicide in men, as it is comorbid with affective illness (Isometsä et al., 1995; Benedetti et al., 2007). Past substance abuse more than tripled the risk of future suicidal acts in men with a major depressive episode, (Oquendo et al., 2007). "
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    International Journal of Qualitative Studies on Health and Well-Being 07/2009; 2(4):246-259. DOI:10.1080/17482620701547008 · 0.93 Impact Factor
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    • "Up to 75% of patients with any bipolar disorder had one or more Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) comorbidities [15]. More specifically, anxiety disorders and substance and alcohol abuse appeared to be relatively common (16–70% for anxiety disorders and 21–34% for substance abuse disorders) among patients with bipolar disorder although this finding was dependent on study inclusion and exclusion criteria [22,26,27]. "
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