Keratoacanthoma developing on nevus sebaceous in a child

Department of Dermatology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
Journal of the American Academy of Dermatology (Impact Factor: 5). 03/2007; 56(2 Suppl):S57-8. DOI: 10.1016/j.jaad.2006.05.022
Source: PubMed
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    ABSTRACT: Nevus sebaceous of Jadassohn is a hamartoma with a combination of abnormalities of the epidermis, hair follicles, and sebaceous and apocrine glands. Herein, we discuss the results of an extensive literature review on the topic of nevus sebaceous with a particular focus on the debate about the necessity for prophylactic excision. We also focus on the documentation of associated malignant tumors that were reported to develop within NS. In addition to reporting the number and types of neoplasms, we documented the recommendations of all authors for therapeutic handling of these nevi.
    Pediatric Dermatology 01/2012; 29(1):15-23. DOI:10.1111/j.1525-1470.2011.01562.x · 1.52 Impact Factor
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    ABSTRACT: : As of 2013, keratoacanthomas (KAs) have not been decided on as either a benign or a malignant entity. Originally considered benign epidermal growths, the assertion by Hodak, Jones, and Ackerman that these lesions are truly "an expression of squamous cell carcinoma" (SCC) fueled the controversy and placed some of the biggest names in the field on opposite sides of the issue. Without a clear understanding of the etiology of KAs and without stringent diagnostic criteria, the literature in regard to KA contains scant reports of their "metastatic potential." Four hundred forty-five cases of KA with reported follow-up and outcomes were reviewed from 113 published articles. In our data set, none of these cases resulted in death or distant metastases. When compared with 429 cases of SCC of the skin, with 61 cases of metastases and 24 deaths as a direct result of SCC, the biologic behavior of the 2 entities is distinct and evident. KAs are benign epidermal growths and not a malignant variant of SCC.
    The American Journal of dermatopathology 12/2013; 36(5). DOI:10.1097/DAD.0000000000000031 · 1.43 Impact Factor