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Vitamin D deficiency in pregnancy: bringing the issues to light.

Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329, USA.
Journal of Nutrition (Impact Factor: 4.23). 03/2007; 137(2):305-6.
Source: PubMed
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    ABSTRACT: Objective: To describe the status of vitamin D levels in maternal and umbilical cord blood in term pregnant woman in a mixed ethnic population in an inner-city European maternity. A single centre prospective cohort descriptive study including all uncomplicated singleton term pregnancies from April 1, 2011 until May 31, 2011. Plasma 25-hydroxy vitamin D level was determined in maternal and umbilical cord blood and data on age, previous obstetric history, ethnicity, nutritional intake and use of vitamin supplements were registered. Complete data were collected in 94 patients. Mean maternal serum vitamin D was 16.6 ng/mL. Using a cut-off of 20 ng/mL, 66% of women were classified as deficient. Deficiency was present in all ethnic groups, but lower levels were noted in North-African, Central-African and Asian women. A strong correlation between maternal and umbilical cord levels was noted (R = 0.91). Number of previous pregnancies and intake of supplements had no influence. The majority of low risk pregnant women showed vitamin D deficiency which was strongly correlated with umbilical cord levels. The prevalence was highest in the immigrant non-European population and was not influenced by intake of vitamin supplements. It can therefore be questioned whether the proposed cut-off values are appropriate.
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    ABSTRACT: The steroid hormone vitamin D is historically recognized for its relevance to bone health and calcium homeostasis. Recent years have witnessed a shift in focus to non-skeletal benefits of vitamin D; in this latter context, an accruing body of literature attests to a relevance of vitamin D to reproductive physiology. This article reviews the existing data about the diverse and previously underappreciated roles for vitamin D in reproductive health. A large body of available literature suggests that vitamin D deficiency may be detrimental to reproductive biology. However, given that our appreciation of vitamin D's role in reproductive physiology is almost entirely shaped by 'associative' studies and that data based on prospective interventional trials are limited, these concepts remain predominantly conjectural. Exact mechanisms whereby vitamin D may participate in the regulation of reproductive physiology remain far from clear. This review underscores a need for appropriately designed intervention trials to address the existing knowledge gaps and to delineate the specific roles of vitamin D signaling in reproductive biology.
    Human Reproduction 07/2012; 27(10):3015-27. DOI:10.1093/humrep/des248 · 4.59 Impact Factor
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    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 01/2012; 116(1):76-7. DOI:10.1016/j.ijgo.2011.09.010 · 1.56 Impact Factor

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