Article

Revised Response Criteria for Malignant Lymphoma

University of Cologne, Köln, North Rhine-Westphalia, Germany
Journal of Clinical Oncology (Impact Factor: 18.43). 03/2007; 25(5):579-86. DOI: 10.1200/JCO.2006.09.2403
Source: PubMed

ABSTRACT Standardized response criteria are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies.
The International Working Group response criteria (Cheson et al, J Clin Oncol 17:1244, 1999) were widely adopted, but required reassessment because of identified limitations and the increased use of [18F]fluorodeoxyglucose-positron emission tomography (PET), immunohistochemistry (IHC), and flow cytometry. The International Harmonization Project was convened to provide updated recommendations.
New guidelines are presented incorporating PET, IHC, and flow cytometry for definitions of response in non-Hodgkin's and Hodgkin's lymphoma. Standardized definitions of end points are provided.
We hope that these guidelines will be adopted widely by study groups, pharmaceutical and biotechnology companies, and regulatory agencies to facilitate the development of new and more effective therapies to improve the outcome of patients with lymphoma.

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    • "The use of PET/CT in HL Hodgkin Lymphoma is 18 FFDG avid in 97–100% of cases (Weiler-Sagie et al, 2010). Staging patients with FDG PET-CT is more accurate than CT alone (Cheson et al, 2007) and the availability of a baseline scan increases the reliability of subsequent response assessment (Quarles van Ufford et al, 2010; Barrington et al, 2011). Contrast-enhanced CT may be done as part of the PET-CT examination or at a separate visit, depending on local imaging arrangements. "
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    ABSTRACT: The guideline group was selected to be representative of UK-based medical experts and patients' representatives. MEDLINE and EMBASE were searched systematically for publications in English from January 1990 to June 2013 using the key words Hodgkin, Lymphoma, Treatment, Chemotherapy and Radiotherapy. References from relevant publications were also searched. The writing group produced the draft guideline, which was subsequently revised by consensus by members of the Haemato-Oncology Task Force of the British Committee for Standards in Haematology (BCSH). The guideline was then reviewed by a sounding board of approximately 50 UK haematologists and the BCSH and comments incorporated where appropriate. The 'GRADE' system was used to quote levels and grades of evidence, details of which can be found in Appendix I. The objective of this guideline is to provide healthcare professionals with clear guidance on the management of patients with classical Hodgkin Lymphoma (HL). The guidance may not be appropriate for all patients with HL and in all cases individual patient circumstances may dictate an alternative approach.
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    • "Patients could continue therapy until disease progression or unacceptable toxicity occurred. Response was assessed by computerized tomography (CT) scan according to the revised response criteria for malignant lymphoma (Cheson et al, 2007). A total of 25 patients also underwent positron emission tomography (PET) for response evaluation. "
    British Journal of Haematology 03/2014; 166(2). DOI:10.1111/bjh.12849 · 4.96 Impact Factor
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    • "Analysis excludes the second retreatment for 3 systemic anaplastic large cell lymphoma patients. a Best response (according to Cheson 2007 "
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