Article

Interictal habituation deficit of the nociceptive blink reflex: An endophenotypic marker for presymptomatic migraine?

Headache Research Unit, University Department of Neurology, University of Liège, Liège, Belgium.
Brain (Impact Factor: 10.23). 04/2007; 130(Pt 3):765-70. DOI: 10.1093/brain/awl351
Source: PubMed

ABSTRACT Habituation of the nociception-specific blink reflex (nBR) is reduced interictally in migraine patients. This could be related to the habituation deficit of evoked cortical responses, a reproducible abnormality in migraine which has a familial character, or to central trigeminal sensitization due to repeated attacks. We compared nBR habituation in healthy volunteers devoid of personal or family history of migraine (HV), in migraine without aura patients (MO) and in healthy volunteers with a family history of migraine in first degree relatives (HV-F). We elicited the nBR by stimulating the right supraorbital region with a custom-built electrode in 16 MO between attacks, 15 HV and 14 HV-F. Habituation was measured as the percentage area-under-the-curve decrease in 10 consecutive blocks of five averaged rectified responses. nBR habituation was clearly reduced in MO and HV-F compared to HV. Percentage area under the curve decreased between the 1st and the 10th block by 55.01% in HV, 25.71% in MO (P = 0.001) and 26.73% in HV-F (P = 0.043). HV-F had the most pronounced abnormality with potentiation instead of habituation in the second block. We found a positive intraindividual correlation between attack frequency and habituation in MO (r = 0.621; P = 0.010). Migraine patients have interictally a deficient habituation of the nBR which is inversely related to attack frequency, suggesting that it is not due to trigeminal sensitization. Surprisingly, the most pronounced habituation deficit is found in asymptomatic individuals with a family history of migraine. Deficient nBR habituation could thus be a trait marker for the genetic predisposition to migraine.

Download full-text

Full-text

Available from: Laura Di Clemente, Jul 30, 2015
0 Followers
 · 
95 Views
  • Source
    • "Moreover, lack of habituation of the iCNV was found in asymptomatic subjects with a positive family history of migraine, defined ''at risk " , and the amplitude of the iCNV correlated significantly with the relative number of subjects suffering from migraine in the family (Siniatchkin et al., 2001). Recently, we performed the same observation with nociceptive blink reflex in a group of healthy asymptomatic subjects having a 1st degree relative affected by migraine (Di Clemente et al., 2007). These findings raise the possibility that subjects with a familial predisposition for migraine may present a presymptomatic neurophysiological abnormality in response habituation, i.e. the same habituation deficit as migraine patients. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The most reproducible and ubiquitous interictal abnormality of the migraineurs' brain is lack of habituation in neuronal information processing. The underlying mechanisms are uncertain. Increased neuronal excitability, decreased inhibition or decreased pre-activation levels have all been proposed as possible culprits. The present review summarizes the available data on habituation in migraine patients obtained with different methodological approaches. We will discuss the change of habituation level over the migraine cycle and we will show that these data congruently indicate that the sensory cortices of migraineurs react excessively to repetitive, but not to a small series of stimuli. Although the precise cellular and molecular mechanisms of this hyper-responsivity must still be determined, we will describe experimental data suggesting that a dysrhythmic thalamo-cortical activity due to inadequate monoaminergic control might be a plausible explanation.
    Neurobiology of Learning and Memory 09/2008; 92(2):249-59. DOI:10.1016/j.nlm.2008.07.006 · 4.04 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The authors propose that allegedly unilateral autonomic stimulation by certain 'vagal maneuvers' triggers amphotropic HR control menus involving sympathetical nonreciprocal response. In a young adult at physical rest, the vagal motor nucleus appears to be subject to 'sliding capture' by the actual prominent, e.g. input, auto-oscillating respiratory/reticular neurons, various reflex afferences or higher centers, as weighted by posture, receptor stimulation, or cortical status. Reciprocal dynamics of the respiratory and lowest band of RR interval spectrum from slow waves sleep to REM points to an useful discriminant in automatic sleep stage scoring.< >
    Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE; 12/1988
  • [Show abstract] [Hide abstract]
    ABSTRACT: In the paper, the authors consider the performance of histogram-based analog to digital converter (ADC) testing under the assumption of input-equivalent wideband noise, which models either noise sources inside the device or unwanted disturbances corrupting the stimulus signal employed for carrying out the test. Theoretical relationships are presented which allow the design of the test parameters needed to meet a given test accuracy. Moreover, it is shown, that the histogram test is effective in providing information on the deterministic behavior of the tested device and that it can be made insensitive to the effects of input-equivalent noise. Finally, the obtained results are employed to determine the test performance in estimating the device effective number of bits, and simulations results are provided which validate the theoretical derivations
    IEEE Transactions on Instrumentation and Measurement 09/1998; 47(4-47):1001 - 1004. DOI:10.1109/19.744658 · 1.71 Impact Factor
Show more