Netherlands Twin Register: From Twins to Twin Families

Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, the Netherlands.
Twin Research and Human Genetics (Impact Factor: 2.3). 01/2007; 9(6):849-57. DOI: 10.1375/183242706779462426
Source: PubMed


In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.

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Available from: Marijn A Distel, Oct 07, 2015
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    • "Participants were recruited from the Netherlands Twin Register (NTR, Boomsma et al., 2006; van Beijsterveldt et al., 2013; Willemsen et al., 2013). Reading scores were collected in two samples . "
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    ABSTRACT: Reading is the processing of written language. Family resemblance for reading (dis)ability might be due to transmission of a genetic liability or due to family environment, including cultural transmission from parents to offspring. Familial-risk studies exploring neurobehavioral precursors for dyslexia and twin studies can only speak to some of these issues, but a combined twin-family study can resolve the nature of the transmitted risk. Word-reading fluency scores of 1100 participants from 431 families (with twins, siblings and their parents) were analyzed to estimate genetic and environmental sources of variance, and to test the presence of assortative mating and cultural transmission. Results show that variation in reading ability is mainly caused by additive and non-additive genetic factors (64%). The substantial assortative mating (rfather-mother=0.38) has scientific and clinical implications. We conclude that parents and offspring tend to resemble each other for genetic reasons, and not due to cultural transmission. Copyright © 2015 Elsevier Inc. All rights reserved.
    Brain and Language 08/2015; DOI:10.1016/j.bandl.2015.07.008 · 3.22 Impact Factor
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    • "The subject sample consisted of 472 males and 668 females from the Netherlands Twin Register (NTR) recruited from all over the Netherlands (Boomsma et al., 2006; van Beijsterveldt et al., 2013; Willemsen et al., 2013). The majority (n = 1110) was comprised of twin pairs and their family members (parents, children, siblings, and spouses) who volunteered in NTR projects. "
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    Brain and Cognition 05/2015; 97:32-39. DOI:10.1016/j.bandc.2015.04.001 · 2.48 Impact Factor
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    • "Treatment seeking was assessed based on the following available information: (i) current use of antidepressant; (ii) use of antidepressant in the last 3 years; (iii) recruited from secondary mental health care; or (iv) received psychotherapy/ counselling in the last 6 months. The NTR (Boomsma et al. 2006) was founded in 1987 and has ascertained large samples of twins and their relatives by questionnaires over the last 18 years. CIDI interview (version 2.1) based on DSM-IV was conducted twice in a subset of the NTR participants in 1997 and 2007, among which there were a total of 94 female samples in the NTR that met the diagnostic criteria for MD. "
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