Acoustic cavitation, bubble dynamics and sonoluminescence. Ultrason Sonochem

Drittes Physikalisches Institut, Universität Göttingen, Friedrich-Hund-Platz 1, D-37077 Göttingen, Germany.
Ultrasonics Sonochemistry (Impact Factor: 4.32). 05/2007; 14(4):484-91. DOI: 10.1016/j.ultsonch.2006.09.017
Source: PubMed


Basic facts on the dynamics of bubbles in water are presented. Measurements on the free and forced radial oscillations of single spherical bubbles and their acoustic (shock waves) and optic (luminescence) emissions are given in photographic series and diagrams. Bubble cloud patterns and their dynamics and light emission in standing acoustic fields are discussed.

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    • "Moreover, the secondary Bjerknes force is responsible for several interesting dynamic phenomena which, among others, include bubble coalescence, formation of stable bubble pairs that move together in the host liquid and the formation of satellite bubbles (Kornfeld & Suvorov 1944). More recently, the field of cavitation gained significant momentum, due to the remarkable phenomenon of single bubble sonoluminescence (Brenner, Hilgenfeldt & Lohse 2002; Lauterborn et al. 2007), which is associated with light emission during collapse of either a cavitating or a laserinduced bubble. During the last decade, there has been an emerging biomedical application of bubbles in the form of contrast agents, which are micron-sized bubbles that are encapsulated in a lipid polymer or albumin shell (Goldberg, Raichlen & Forsberg 2001; Tsiglifis & Pelekasis 2008). "
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    ABSTRACT: According to linear theory and assuming the liquids to be inviscid and the bubbles to remain spherical, bubbles set in oscillation attract or repel each other with a force that is proportional to the product of their amplitude of volume pulsations and inversely proportional to the square of their distance apart. This force is attractive, if the forcing frequency lies outside the range of eigenfrequencies for volume oscillation of the two bubbles. Here we study the nonlinear interaction of two deformable bubbles set in oscillation in water by a step change in the ambient pressure, by solving the Navier–Stokes equations numerically. As in typical experiments, the bubble radii are in the range 1–1000 μm. We find that the smaller bubbles (~5 μm) deform only slightly, especially when they are close to each other initially. Increasing the bubble size decreases the capillary force and increases bubble acceleration towards each other, leading to oblate or spherical cap or even globally deformed shapes. These deformations may develop primarily in the rear side of the bubbles because of a combination of their translation and harmonic or subharmonic resonance between the breathing mode and the surface harmonics. Bubble deformation is also promoted when they are further apart or when the disturbance amplitude decreases. The attractive force depends on the Ohnesorge number and the ambient pressure to capillary forces ratio, linearly on the radius of each bubble and inversely on the square of their separation. Additional damping either because of liquid compressibility or heat transfer in the bubble is also examined.
    Journal of Fluid Mechanics 04/2011; 673:513 - 547. DOI:10.1017/S0022112010006361 · 2.38 Impact Factor
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    • "Ultrasonically induced cavitation is the primary cause of sonoluminescence and acoustical emissions such as subharmonic emissions . It may have potential applications in cleaning, emulsifying, promoting chemical reactions, enhancing sonoluminescence [1] [2] and facilitating medical treatments such as transdermal drug transport [3] [4], sonophoresis, sonodynamic therapy, chemotherapy, gene and apoptosis therapy and drug delivery [5] [6] [7] [8] [9] [10]. "
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    ABSTRACT: Evaluation of inertial cavitation is a significant problem where this mechanism of action is responsible for therapeutic applications such as drug delivery. It has shown that using multiple frequencies one is able to enhance and control induced cavitation. In this study, we used different sonication frequencies as 28 kHz, 130 kHz, 1 MHz, 3 MHz and their dual combinations to enhance acoustic cavitation. At each frequency, two different intensities were used and the subharmonic amplitude of each frequency in combinations was measured. It was observed that in combinations which include 28 kHz, the cavitation activity is enhanced. The 28 kHz subharmonic amplitude was used to compare these protocols in their ability to enhance cavitation. Besides, the area of cavitation damage was determined using an aluminum foil. Our results showed that the inertial cavitation activity increased at higher intensities and there is a significant correlation between the subharmonic amplitude and sonication intensity at each frequency (R>0.90). In addition, simultaneous combined dual-frequency orthogonal sonication at 28 kHz with other frequencies used can significantly increase the inertial cavitation activity as compared to the algebraic sum of the individual ultrasound irradiations in 28 kHz subharmonic frequency. The 28 kHz subharmonic amplitude for 28 kHz (0.04 W/cm(2)) and 3 MHz (2 and 1 W/cm(2)) combined dual frequency were about 4.6 and 1.5 times higher than that obtained from the algebraic sum of 28 kHz and 3 MHz irradiation, respectively. Also the 28 kHz subharmonic amplitude for combination of 28 kHz (0.04 W/cm(2)) and 1 MHz (2 and 1 W/cm(2)) were about 2.4 and 1.6 times higher than that obtained with their algebraic sum. Among different combinations, the continuous mode for two ultrasound sources of 28 kHz (0.04 W/cm(2)) and 3 MHz (2 W/cm(2)) is more effective than other combinations (p-value<0.05). The results of effective irradiation area showed no damaged aluminum foil in MHz sonication alone. However, there is significant difference between the effective irradiation area of combined dual frequency 28 kHz and 3 MHz with other irradiation modes (p-value<0.05) and it is limited locally.
    Ultrasonics Sonochemistry 01/2011; 18(1):394-400. DOI:10.1016/j.ultsonch.2010.07.005 · 4.32 Impact Factor
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    • "Forces created during acoustic cavitation (Apfel 1982, Lauterborn et al. 2007) can transiently disrupt the plasma membrane, to allow intracellular uptake (Brayman et al. 1999, Miller et al. 2002, Schlicher et al. 2006). Ultrasound exposure can also result in cellular and tissue damage (Alter et al. 1998, Bailey et al. 1983) and cell death via routes including both necrosis and apoptosis (Cochran and Prausnitz 2001, Feril and Kondo 2004, Miller and Dou 2009, Miller and Quddus 2002). "
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    ABSTRACT: Acoustic cavitation-mediated wounding (i.e., sonoporation) has great potential to improve medical and laboratory applications requiring intracellular uptake of exogenous molecules; however, the field lacks detailed understanding of cavitation-induced morphologic changes in cells and their relative importance. Here, we present an in-depth study of the effects of acoustic cavitation on cells using electron and confocal microscopy coupled with quantitative flow cytometry. High resolution images of treated cells show that morphologically different types of blebs can occur after wounding conditions caused by ultrasound exposure as well as by mechanical shear and strong laser ablation. In addition, these treatments caused wound-induced nonlytic necrotic death resulting in cell bodies we call wound-derived perikarya (WD-P). However, only cells exposed to acoustic cavitation experienced ejection of intact nuclei and nearly instant lytic necrosis. Quantitative analysis by flow cytometry indicates that wound-derived perikarya are the dominant morphology of nonviable cells, except at the strongest wounding conditions, where nuclear ejection accounts for a significant portion of cell death after ultrasound exposure.
    Ultrasound in medicine & biology 04/2010; 36(4):677-92. DOI:10.1016/j.ultrasmedbio.2010.01.010 · 2.21 Impact Factor
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