Pathological diagnosis of granulomatous lung disease: a review

Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Histopathology (Impact Factor: 3.3). 03/2007; 50(3):289-310. DOI: 10.1111/j.1365-2559.2006.02546.x
Source: PubMed

ABSTRACT Granulomas in the lung are common diagnostic problems encountered by pathologists. They occur in a wide range of pulmonary conditions, ranging from common entities to uncommon ones and including both infections and non-infectious diseases. This review summarizes the main histological features that help distinguish various granulomatous lung diseases. It concentrates on the most important and common entities that may be encountered and emphasizes helpful features in the differential diagnosis.

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    Journal of Investigative Medicine 05/2014; 62(6). DOI:10.1097/01.JIM.0000446837.75352.3b · 1.50 Impact Factor
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    ABSTRACT: Introduction. Diagnosis of tuberculous and sarcoid granulomas is frequent in routine pathological practice. Tuberculosis and sar - coidosis have lately been considered to be the same disease but with different manifestations or two different diseases with the same manifestations because of the presence of the same antigens that stimulate formation of granulomas. That is why the differen - tial diagnosis of sarcoidosis and tuberculosis could be difficult on biopsies. The aim of this study was to point to the difficulties met by a pathologist in diagnosing tuberculosis and sarcoidosis. Re - sults. In case of typical morphology, the differentiation of sar - coidosis and tuberculosis is simple. In the presence of productive granulomas in tuberculosis or necrotizing granulomas in sar - coidosis, it is difficult to establish the pathological diagnosis with - out clinical data. The role of the pathologist in diagnosing sar - coidosis and tuberculosis is to establish the presence of granulo - mas and to suggest the diagnosis according to its morphology. The definitive diagnosis requires a multidisciplinary approach of pulmonologists, radiologists, microbiologists, immunolo -gists, biochemists and pathologists.
    Medicinski pregled 12/2013; LXVI(Suppl 1):34-38. DOI:10.2298/MPNS13S1034
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