Solitary metastatic cancer to the thyroid: a report of five cases with fine-needle aspiration cytology
ABSTRACT Three men and 2 women with ages ranging from 37 to 70 years, clinically and histologically confirmed solitary, palpable metastatic cancers to the thyroid (SMCT) and preoperative cytologic investigation of their thyroid lesions by fine-needle aspiration (FNA), were reviewed. Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer. Direct smears prepared from the patients' thyroid FNAs were fixed in 95% ethanol and stained with the Papanicolaou method. In 3 cases, immunostaining of the aspirated tumor cells with thyroglobulin antibody was performed, and in 1 case an aspiration smear was stained with commercial HMB-45 antibody. A correct cytodiagnosis of metastatic cancer to the thyroid was made in all 5 cases. In 1 patient the thyroid FNA revealed a metastatic RCC that led to the discovery of a clinically occult RCC. All 5 patients died of metastatic disease 27 to 40 months after surgical resection of their SMCTs.
- SourceAvailable from: cytoindia.com[Show abstract] [Hide abstract]
ABSTRACT: Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region. Its occurrence elsewhere is rare and extension to thyroid even rarer. We report a 27 year old male who was diagnosed to have features of adenoid cystic carcinoma in fine needle aspirate of the thyroid swelling and subsequently confirmed by histopathology. Extensive search failed to reveal a primary. Awareness of cytology of adenoid cystic carcinoma and unusual presentation can help in making a diagnosis on cytology. Journal of Cytology 2007; 24 (3) : 151-152Journal of Cytology 01/2007; 24(3). DOI:10.4103/0970-9371.41909 · 0.41 Impact Factor
- CytoJournal 02/2008; 5:15. DOI:10.4103/1742-6413.44572
- [Show abstract] [Hide abstract]
ABSTRACT: The thyroid gland is a rare site of clinically detectable tumor metastasis and kidneys are frequently the site of the parent malignancy. In the present review on thyroid metastases from renal cell carcinoma, cases were searched on PubMed by entering the strings: "renal carcinoma [or "hypernephroma"] AND thyroid metastasis/metastases". Thus, we retrieved a total of 111 cases that were published between 1964 and 2007, a total that became 113 by adding two patients observed by us. The female to male ratio was 1.35:1. The primary renal cancer was almost always unilateral (90%) (with no significant side preference) and only rarely bilateral (9% in men, 4% in women), whereas bilaterality of thyroid metastases was relatively more frequent (28%). Thyroid metastasis from renal cancer was commonly single with a unique node that appears solid and hypoechoic at ultrasonography, approximately 9 years after nephrectomy. Concordance of lateralization was insignificantly greater for the right kidney/right thyroid lobe pattern (54%) than for the left kidney/left thyroid lobe pattern (40%), regardless of gender. Finally, survival was longer for women. Thyroid metastases, even if rare in the clinical practice, must be considered in the differential diagnosis of a thyroid nodule, particularly in patients who have a history of malignancies.The Scientific World Journal 01/2010; 10:590-602. DOI:10.1100/tsw.2010.55 · 1.73 Impact Factor