N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.
ABSTRACT A series of N-benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine monoamine reuptake inhibitors are described. Selective dual 5-HT and NA reuptake inhibition was achieved, and analogues with weak CYP2D6 inhibition, good human in vitro metabolic stability and wide ligand selectivity, such as 12b, were identified.
- Expert Opinion on Therapeutic Patents 08/2007; 17(8):889-907. · 3.53 Impact Factor
- Bioorganic & medicinal chemistry letters 06/2010; 20(12):3788-92. · 2.65 Impact Factor