Prepubertal gynecomastia linked to lavender and tea tree oils.
ABSTRACT Most cases of male prepubertal gynecomastia are classified as idiopathic. We investigated possible causes of gynecomastia in three prepubertal boys who were otherwise healthy and had normal serum concentrations of endogenous steroids. In all three boys, gynecomastia coincided with the topical application of products that contained lavender and tea tree oils. Gynecomastia resolved in each patient shortly after the use of products containing these oils was discontinued. Furthermore, studies in human cell lines indicated that the two oils had estrogenic and antiandrogenic activities. We conclude that repeated topical exposure to lavender and tea tree oils probably caused prepubertal gynecomastia in these boys.
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ABSTRACT: Gynecomastia is defined as the excessive development of breast tissue in males, which can occur as unilateral or bilateral. Although the overall prevalence of gynecomastia is 40%-65%, the prepubertal unilateral gynecomastia in the absence of endocrine abnormalities is unusual, with only a few case reports in literature. Idiopathic gynecomastia in prepuberty is benign but a diagnosis of exclusion. We here report two cases of healthy prepubertal boys aged 8.8 and 9.6 years old, respectively, presented with painful palpable mass in their unilateral breast. Breast tissue with glandular proliferation was confirmed on ultrasonography. Serum levels of estradiol, testosterone, and other laboratory findings were within normal range. They seem to have the prepubertal idiopathic gynecomastia but further follow-up to see their progression is needed.Annals of pediatric endocrinology & metabolism. 09/2014; 19(3):159-63.
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ABSTRACT: Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.Journal of Clinical Research in Pediatric Endocrinology 12/2014; 6(4):250-253.
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ABSTRACT: Klinefelter’s syndrome is an important common sex chromosomal abnormality in humans and it remains an important genetic cause of male infertility. A 12-year-old student was referred to our hospital due to presence of small penis and testes since birth and progressive breast enlargement of five years duration. On examination, the height was 1.64 metres and weight was 75kg. Breasts and axillary hairs were well developed at Tanner stage IV and III respectively and hair distribution of external genitalia was at Tanner stage IV. The penis and testes were small but well developed. There was no hypospadias or epispadias. Transperineal and transrectal ultrasound showed no ovaries or uterus. Hormonal profile was normal except low Follicle stimulating hormone. Karyotype was 47 XXY. Parent was concerned with the gynecomastia and subsequently was referred to general surgeon for mastectomy. We reported a first case of Klinefelter’s syndrome in an adolescent presenting to our gynecology clinic. The various forms of differential diagnoses of gynecomastia were discussed.Obstet Gynecol Cases Rev. 10/2014; 1(1):2-4.