Article

Type II Polyketide Synthases: Gaining a Deeper Insight into Enzymatic Teamwork

Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.
Natural Product Reports (Impact Factor: 10.72). 03/2007; 24(1):162-90. DOI: 10.1039/b507395m
Source: PubMed

ABSTRACT This review covers advances in understanding of the biosynthesis of polyketides produced by type II PKS systems at the genetic, biochemical and structural levels.

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Available from: Andriy Luzhetskyy, Jul 31, 2015
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    • "In analogy with the evolutionarily related fatty acid synthases, they are classified into Type I and Type II PKSs (Hopwood and Sherman, 1990; Smith and Tsai, 2007). The latter sub-class of PKSs, which resemble bacterial and plant fatty acid synthases, play a defining role in the biosynthesis of many polycyclic aromatic antibiotics produced by the actinomycetes (Das and Khosla, 2009; Hertweck et al., 2007). They invariably harbor a minimal PKS module comprised of a ketosynthase (KS), a chain length factor (CLF), an acyl carrier protein (ACP), and a malonyl-CoA:ACP transacylase (MAT, usually from the housekeeping fatty acid synthase in the bacterium). "
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