Summary statement IV: Obesity and diabetes: Opportunities for translation of basic research

Division of Diabetes Translation, NCCD-PHP, CoCHP, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Vascular Pharmacology (Impact Factor: 3.64). 06/2007; 46(5):324-6. DOI: 10.1016/j.vph.2006.10.015
Source: PubMed


The worldwide epidemics of obesity and diabetes that have emerged in the 21st century are creating a major public heath problem, having struck developed countries as well as those still developing. With our present clinical tools, abilities, and understanding, we may not be prepared to respond adequately to the demands or be able to engage in effective prevention strategies. The underlying pathophysiological reasons for the increases in both obesity and diabetes may be closely related through abnormality in endothelial cells. Diverse expertise from within and outside the public health arena will be needed to explore the health implications from an "endothelium" perspective and identify those at risk for the development of chronic disease. Identification of new biological markers and better measures of current biological marker will both be critical in understanding and addressing the ongoing epidemic of chronic diseases.

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    ABSTRACT: The gap in the translation of scientific advances from the laboratory to clinical practice is wide and remains an important challenge (Contopoulos-Ioannidis et al., 2003 and Crowley, 2003), as noted by former National Heart, Lung, and Blood Institute Director Claude Lenfant during the 113th Shattuck Lecture (Lenfant, 2003). An even greater challenge is the translation of these advances into public health practice for health promotion and the prevention of diseases and their risk factors. The 8th International Conference on the Vascular Endothelium brought together clinicians, basic scientists, and for the first time in this series of conferences, public health officials to begin to address these challenges. This multidisciplinary group discussed recent advances in endothelial cell biology, then generated ideas on how best to apply these advances to public health practice, with special emphasis on health promotion and chronic disease prevention. Discussions at the conference form the basis for this supplement. Part I of this editorial reviews the advances in endothelial cell biology presented at the conference (Catravas, in press), and part II explores the scientific basis for health promotion and chronic disease prevention, as well as the relationships between normal endothelial cell biology and core public health interventions to prevent chronic diseases (Mensah, 2007-this issue). A series of six summary statements for advancing the translation of the science into public health practice follows, with focuses on prevention, different chronic diseases, and research directions for the future (Engelgau et al., 2007-this issue, Hooper et al., 2007-this issue-a, Hooper et al., 2007-this issue-b, Mensah et al., 2007-this issue-a, Mensah et al., 2007-this issue-b and Reed et al., 2007-this issue). Strategies and approaches within these summary statements reflect the views of the authors and the conference participants and should not be construed as representing an official position of their affiliated institutions or agencies. Participants at the 8th International Conference on the Vascular Endothelium acknowledged that translating scientific advances into clinical and public health practice, while a priority, is much easier said than done. Yet increased collaborations between vascular biology centers and the public health community must be encouraged and nurtured as a first step toward this ideal. Although these collaborations began at the conference, our challenge now is to keep the enthusiasm and commitments alive to eliminate translational gaps and to reap maximal returns on investments made in basic biomedical research on the vascular endothelium.
    Vascular Pharmacology 05/2007; .(5). DOI:10.1016/j.vph.2006.10.012 · 3.64 Impact Factor
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    Diabetes 12/2007; 56(11):2653-4. DOI:10.2337/db07-0951 · 8.10 Impact Factor
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    ABSTRACT: The aim of the present study was to assess the anti-obesity effects of fermented kochujang supplement in C57BL/6J mice. Thirty mice were divided into 3 groups; normal diet control group (ND), high fat diet control group (HD), and high fat diet plus kochujang supplemented group (HDK). Results were as follows: 1. Fermented kochujang supplement in high fat diet decreased body weight and epidydimal and back fat weight compared to non-supplement in HD group. 2. Lipid content and blood glucose level were lower in HDK group than HD group. 3. Fermented kochujang supplement increased mRNA level of lipolytic genes such as acyl-CoA synthetase (ACS), carnitine palmitoyltransferase-1 (CPT-1), and uncoupling proteins-1 (UCP-1) expression, whereas decreased mRNA level of adipogenic genes such as acetyl CoA carboxylase (ACC) expression. These findings suggest that fermented kochujang supplement in high fat diet normalized body weight, epididymal and back fat weight, lipid content, and blood glucose levels through controlling lipid metabolism and provides basic information on the control of obesity.
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