Multifunctional flexible parylene-based intracortical microelectrodes
ABSTRACT Delivering drugs directly to the brain tissue opens new approaches to disease treatment and improving neural interfaces. Several approaches using neural prostheses have been made to deliver drugs directly with bypassing the blood-brain barrier (BBB) [1, 2]. In this paper, we propose a new polymer-based flexible microelectrode with drug delivery capability. The probe was fabricated and tested for electrical and fluidic functionality in early stage design. In vivo chronic recording experiments succeeded in demonstrating the in vivo reliability of the probe. Successful in vivo experiments confirm the suitability of the probes as implantable chronic recording devices with robust fluid delivery function.
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ABSTRACT: Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.Current Opinion in Solid State and Materials Science 12/2014; 18(6). DOI:10.1016/j.cossms.2014.07.005 · 7.17 Impact Factor
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ABSTRACT: This paper presents the fabrication and characteristics of implantable and flexible cuff electrode for neural interfaces using conventional BioMEMS technique. In order to have cuff shape and flexibility of nerve electrode, polyimide was chosen as a substrate material. As electrode materials, platinum and iridium film were deposited with different working pressure of DC magnetron sputter. Electrical properties of both films were characterized by electrochemical spectroscopy (EIS). And also, charge storage capacity of both films were measured and calculated by cyclic voltammogram (CV). Based on experimental results, iridium film deposited at high working pressure shows excellent electrochemical properties such as a low impedance and large charge storage capacity. To evaluate a flexible nerve cuff electrode under in-vivo test, it was implanted at the sciatic nerve of white male rabbit and then connected with electromyography instrument.International IEEE/EMBS Conference on Neural Engineering 01/2009; DOI:10.1109/NER.2009.5109239