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Multifunctional flexible parylene-based intracortical microelectrodes

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 02/2005; 5:5272-5. DOI: 10.1109/IEMBS.2005.1615669
Source: PubMed

ABSTRACT Delivering drugs directly to the brain tissue opens new approaches to disease treatment and improving neural interfaces. Several approaches using neural prostheses have been made to deliver drugs directly with bypassing the blood-brain barrier (BBB) [1, 2]. In this paper, we propose a new polymer-based flexible microelectrode with drug delivery capability. The probe was fabricated and tested for electrical and fluidic functionality in early stage design. In vivo chronic recording experiments succeeded in demonstrating the in vivo reliability of the probe. Successful in vivo experiments confirm the suitability of the probes as implantable chronic recording devices with robust fluid delivery function.

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    • "Fig. 1 shows examples of polyimidebased electrode architecture. Parylene-C is also considered to be a suitable material which can serve as a flexible substrate backbone [154] [111] [132] [68]. These types of electrodes reduced the strain forces between the tissue and the devices caused by micromotion , which can potentially enhance the devices' functional longevity . "
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