Multifunctional Flexible Parylene-Based Intracortical Microelectrodes

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 02/2005; 5:5272-5. DOI: 10.1109/IEMBS.2005.1615669
Source: PubMed


Delivering drugs directly to the brain tissue opens new approaches to disease treatment and improving neural interfaces. Several approaches using neural prostheses have been made to deliver drugs directly with bypassing the blood-brain barrier (BBB) [1, 2]. In this paper, we propose a new polymer-based flexible microelectrode with drug delivery capability. The probe was fabricated and tested for electrical and fluidic functionality in early stage design. In vivo chronic recording experiments succeeded in demonstrating the in vivo reliability of the probe. Successful in vivo experiments confirm the suitability of the probes as implantable chronic recording devices with robust fluid delivery function.

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Available from: Daryl Kipke, Aug 25, 2015
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    • "Fig. 1 shows examples of polyimidebased electrode architecture. Parylene-C is also considered to be a suitable material which can serve as a flexible substrate backbone [154] [111] [132] [68]. These types of electrodes reduced the strain forces between the tissue and the devices caused by micromotion , which can potentially enhance the devices' functional longevity . "
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    ABSTRACT: Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.
    Current Opinion in Solid State and Materials Science 12/2014; 18(6). DOI:10.1016/j.cossms.2014.07.005 · 6.24 Impact Factor
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    • "In general, these devices have limited functionality, allowing for only electrical stimulation and/or recording [5] [6] [11] [12] [13] [14] [15] or only chemical sensing [16]. Initial work has concentrated on incorporating fluidic channels for drug delivery into these neural interfaces [7] [8] [9] [10] [17] [18]. "
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    ABSTRACT: We present here a microfabricated, multi-functional neural interface with the ability to selectively apply electrical and chemical stimuli, while simultaneously monitoring both electrical and chemical activity in the brain. Such a comprehensive approach is required to understand and treat neuropsychiatric disorders, such as major depressive disorder (MDD), and to understand the mechanisms underlying treatments, such as pharmaceutical therapies and deep brain stimulation (DBS). The polymer-based, multi-functional neural interface is capable of electrical stimulation and recording, targeted drug delivery, and electrochemical sensing. A variety of different electrode and fluidic channel arrangements are possible with this fabrication process. Preliminary testing has shown the suitability of these neural interfaces for in vivo electrical stimulation and recording, as well as in vitro chemical sensing. Testing of the in vitro drug delivery and combined in vivo functionalities this neural interface are currently underway.
    Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 07/2013; 2013:5159-5162. DOI:10.1109/EMBC.2013.6610710
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