Quantitative evaluation of the relative cell permeability of peptoids and peptides

Department of Internal Medicine and Division of Translational Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Journal of the American Chemical Society (Impact Factor: 11.44). 03/2007; 129(6):1508-9. DOI: 10.1021/ja0668623
Source: PubMed

ABSTRACT We evaluated quantitatively the relative cell permeability of peptides and peptides using a cell-based reporter gene-based assay. Generally, peptoids were much more cell permeable than the corresponding peptides, though the difference decreased with increasing length. These results suggest that peptoids may be useful reagents for manipulating the activities of intracellular proteins.

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