Caffeinated beverage intake and the risk of heart disease mortality in the elderly: a prospective analysis

Brooklyn College of the City University of New York, New York, NY 11210, USA.
American Journal of Clinical Nutrition (Impact Factor: 6.77). 02/2007; 85(2):392-8.
Source: PubMed

ABSTRACT Motivated by the possibility that caffeine could ameliorate the effect of postprandial hypotension on a high risk of coronary events and mortality in aging, we hypothesized that caffeinated beverage consumption decreases the risk of cardiovascular disease (CVD) mortality in the elderly.
The objective of the study was to use prospective cohort study data to test whether the consumption of caffeinated beverages exhibits this protective effect.
Cox regression analyses were conducted for 426 CVD deaths that occurred during an 8.8-y follow-up in the prospective first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. The analysis involved 6594 participants aged 32-86 y with no history of CVD at baseline.
Participants aged >or=65 y with higher caffeinated beverage intake exhibited lower relative risk of CVD and heart disease mortality than did participants with lower caffeinated beverage intake. It was a dose-response protective effect: the relative risk (95% CI) for heart disease mortality was 1.00 (referent), 0.77 (0.54, 1.10), 0.68 (0.49, 0.94), and 0.47 (0.32, 0.69) for <0.5, 0.5-2, 2-4, and >or=4 servings/d, respectively (P for trend = 0.003). A similar protective effect was found for caffeine intake in mg/d. The protective effective was found only in participants who were not severely hypertensive. No significant protective effect was found in participants aged <65 y or in cerebrovascular disease mortality for those aged >or=65 y.
Habitual intake of caffeinated beverages provided protection against the risk of heart disease mortality among elderly participants in this prospective epidemiologic analysis.

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    • "Caffeine, besides influencing cognitive performance, increases the perception of alertness and wakefulness [105] [106] and sometimes induces anxiety, especially at high doses [107] [108] [109]. Furthermore, antagonism of A 1 and A 2 receptors can cause seizures and cerebral vasoconstriction. "
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    ABSTRACT: Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. Coffee and caffeine-containing products affect the cardiovascular system, with their positive inotropic and chronotropic effects, and the central nervous system, with their locomotor activity stimulation and anxiogenic-like effects. Thus, it is of interest to examine whether these effects could be detrimental for health. Furthermore, caffeine abuse and dependence are becoming more and more common and can lead to caffeine intoxication, which puts individuals at risk for premature and unnatural death. The present review summarizes the main findings concerning caffeine’s mechanisms of action (focusing on adenosine antagonism, intracellular calcium mobilization, and phosphodiesterases inhibition), use, abuse, dependence, intoxication, and lethal effects. It also suggests that the concepts of toxic and lethal doses are relative, since doses below the toxic and/or lethal range may play a causal role in intoxication or death. This could be due to caffeine’s interaction with other substances or to the individuals&apos preexisting metabolism alterations or due to caffeine’s interaction with other substances or to individuals’ pre-existing diseases or metabolism alterations.
    Current Neuropharmacology 04/2015; 13(1):71-88. DOI:10.2174/1570159X13666141210215655 · 3.05 Impact Factor
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    • "It affects the brain and results in a relaxed mood, decreased fatigue, increased focus, and faster, and clear thoughts. Moderate consumption of caffeine, help in reducing the risks of several chronic diseases like Diabetes, Parkinson's diseases, liver disease, and colon cancer, as well as improve immune function [9]. However, excess consumption of CAF cause trembling, nausea, nervousness, and mutational effects such as inhibition of DNA [10]. "
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    ABSTRACT: Electrochemical methods have been widely used for the determination of electroactive compounds due to their simplicity, sensitivity, stability, and low cost. A carbon paste electrode was modified with anthraquinone. Cyclic voltammetry (CV) was employed to study the properties of the modified electrode toward the oxidation of caffeine (CAF). Compared to the unmodified electrode, the AQMCPE showed excellent catalytic activity for the oxidation of caffeine. AQMCPE was used to determine CAF in drug samples electrochemically. SWV was used to plot the calibration curve and there was a good linear relationship between anodic peak current and CAF concentration in the range 2.0 × 10−6 − 8.0 × 10–4 M, with the correlation coefficient of 0.998 and a detection limit of 1.43 × 10−7 M. The application of the modified electrode for the determination of CAF in pharmaceutical formulation showed good recovery with reproducible results.
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    • "Coffee consumption may possibly reduce the risk of myocardial infarction, but data are as yet inconclusive [91, 92]. A dose-response decrease in cardiovascular risk and heart disease mortality was reported for a daily caffeine intake in patients with type 2 diabetes [93, 94]. "
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    ABSTRACT: Cardiovascular disease (CVD) is now the leading cause of death globally and is a growing health concern. Dietary factors are important in the pathogenesis of CVD and may to a large degree determine CVD risk, but have been less extensively investigated. Functional foods are those that are thought to have physiological benefits and/or reduce the risk of chronic disease beyond their basic nutritional functions. The food industry has started to market products labelled as "functional foods." Although many review articles have focused on individual dietary variables as determinants of CVD that can be modified to reduce the risk of CVD, the aim of this current paper was to examine the impact of functional foods in relation to the development and progression of CVD. Epidemiologic studies have demonstrated the association between certain dietary patterns and cardiovascular health. Research into the cardio-protective potential of their dietary components might support the development of functional foods and nutraceuticals. This paper will also compare the effect of individual bioactive dietary compounds with the effect of some dietary patterns in terms of their cardiovascular protection.
    Journal of nutrition and metabolism 04/2012; 2012(12):569486. DOI:10.1155/2012/569486
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