Corrigendum to “Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma” [Free Radic. Biol. Med. 42 (2007) 665–674]

Department of Surgery, Louisiana State University Medical Center, New Orleans, LA 70006, USA.
Free Radical Biology and Medicine (Impact Factor: 5.74). 04/2007; 42(5):665-74. DOI: 10.1016/j.freeradbiomed.2006.12.005
Source: PubMed


Asthma is an increasingly common disorder responsible for considerable morbidity and mortality. Although obesity is a risk factor for asthma and weight loss can improve symptoms, many patients do not adhere to low calorie diets and the impact of dietary restriction on the disease process is unknown. A study was designed to determine if overweight asthma patients would adhere to an alternate day calorie restriction (ADCR) dietary regimen, and to establish the effects of the diet on their symptoms, pulmonary function and markers of oxidative stress, and inflammation. Ten subjects with BMI>30 were maintained for 8 weeks on a dietary regimen in which they ate ad libitum every other day, while consuming less than 20% of their normal calorie intake on the intervening days. At baseline, and at designated time points during the 8-week study, asthma control, symptoms, and Quality of Life questionnaires (ACQ, ASUI, mini-AQLQ) were assessed and blood was collected for analyses of markers of general health, oxidative stress, and inflammation. Peak expiratory flow (PEF) was measured daily on awakening. Pre- and postbronchodilator spirometry was obtained at baseline and 8 weeks. Nine of the subjects adhered to the diet and lost an average of 8% of their initial weight during the study. Their asthma-related symptoms, control, and QOL improved significantly, and PEF increased significantly, within 2 weeks of diet initiation; these changes persisted for the duration of the study. Spirometry was unaffected by ADCR. Levels of serum beta-hydroxybutyrate were increased and levels of leptin were decreased on CR days, indicating a shift in energy metabolism toward utilization of fatty acids and confirming compliance with the diet. The improved clinical findings were associated with decreased levels of serum cholesterol and triglycerides, striking reductions in markers of oxidative stress (8-isoprostane, nitrotyrosine, protein carbonyls, and 4-hydroxynonenal adducts), and increased levels of the antioxidant uric acid. Indicators of inflammation, including serum tumor necrosis factor-alpha and brain-derived neurotrophic factor, were also significantly decreased by ADCR. Compliance with the ADCR diet was high, symptoms and pulmonary function improved, and oxidative stress and inflammation declined in response to the dietary intervention. These findings demonstrate rapid and sustained beneficial effects of ADCR on the underlying disease process in subjects with asthma, suggesting a novel approach for therapeutic intervention in this disorder.

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    • "However, anti-inflammatory therapies have shown mixed and discouraging results (Imbimbo et al., 2010; In t' Veld et al., 2001; Stewart et al., 1997; Vlad et al., 2008). Dietary strategies visibly influence inflammation, as related through both observational studies and controlled feeding trials in which subjects had limited food consumption (Giugliano et al., 2006; Harvie et al., 2011; Johnson et al., 2007; Mozaffarian et al., 2009). The most prominent dietary factor that affects the risk of many different chronic diseases is energy intake. "
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    • "In line with these observations , it has been demonstrated that fasting facilitates longterm memory formation in Drosophila melanogaster (Hirano et al., 2013). Moreover, alternate day fasting over a period of 2–4 weeks reduces asthma-related symptoms and markers of oxidative stress in overweight people suffering from asthma (Johnson et al., 2007). Marked reduction of metabolic disease markers, such as high blood pressure and levels of circulating IGF1 and C-reactive protein, has been reported in overweight women that were subjected to a 2 day per week fast over 6 months (Harvie et al., 2011). "
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