Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boron-rich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 +/- 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P < 0.0001). Women from the boron-rich regions had no cytopathological indications of cervical cancer, while there were cytopathological findings for 15 women from the boron-poor areas (chi(2) = 10.473, P < 0.05). Sixty women, 30 from each region, were chosen for evaluating MN frequencies in exfoliated buccal cells. MN frequencies for women from the boron-rich and boron-poor regions were not significantly different (t = -0.294, P > 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r = 0.133, P = 0.48, P > 0.05) and boron-poor (r = -0.033, P = 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers.
"Linearity was checked in the range of 0-40 µg g -1 . Detection limits were calculated as the concentrations of an element that gave a signal equal to three times the standard deviation of a series of ten successive measurements of the blank solution at the element peak (Korkmaz et al., 2007). "
[Show abstract][Hide abstract] ABSTRACT: This study was conducted to determine the effects of sewage sludge (SS) used as fertilizer at different concentrations [Control, 20 kg ha–1 nitrogen (N), 30 ton ha–1 SS (S1), 60 ton ha–1 SS (S2) and 90 ton ha–1 SS (S3), 20 kg ha–1 N + 30 ton ha-1 SS (N + S1), 20 kg ha–1 N + 60 ton ha–1 SS (N + S2) and 20 kg ha–1 N + 90 ton ha–1 SS (N + S3)] on common vetch yields and chemical features. For this purpose, an increasing level of SS was applied to the soil samples. The residuals of some heavy metal (Hg, Cr, Fe, Ni, Zn, Mn, Cd, Pb, Cu, Co, and Se) and macro element (K, Ca, Na, Mg, C, and S) concentrations were measured in leafs, seeds and soils. According to the results of this study, SS, when applied to soil in increasing amounts, raised the mineral matter contents of the plants, which favorably affected plant growth. Accordingly, it affected the herbage yield, increasing the yield in parallel with the increasing SS concentrations. Applying N with the SS positively influenced the heavy metal contents on leafs and seeds of common vetch and residue in the soil. Besides, the heavy metal contents were found at below critical levels in the soil, leaf and seeds. Therefore, SS application as fertilizer used in appropriate concentrations did not pollute the soil very much, but did lead to an increase in plant products.
Legume Research 08/2015; 38(4):488-495. DOI:10.5958/0976-0571.2015.00133.2 · 0.15 Impact Factor
"The reason boron compounds are selected to be substituted at the ZBG and CAP is because the clinical trials have shown that consumption of boron may prevent cervical cancer caused by HPV [37, 39]. By consuming the boron content of 84.1 mg per day, it could prevent cervical cancer . The forms of a functional group of boron compounds that have been proven to have therapeutic effects till date are diazoborin, boronic acid, boronic ester, and benzoxaborole . "
[Show abstract][Hide abstract] ABSTRACT: Histone deacetylase (HDAC) has a critical function in regulating gene expression. The inhibition of HDAC has developed as an interesting anticancer research area that targets biological processes such as cell cycle, apoptosis and cell differentiation. In this study, an HDAC inhibitor that is available commercially, suberoyl anilide hydroxamic acid (SAHA) has been modified to improve its efficacy and reduce the side effects of the compound. Hydrophobic cap and zinc-binding group of these compounds were substituted with boron-based compounds, whereas the linker region was substituted with p-aminobenzoic acid. The molecular docking analysis resulted in 8 ligands with $Delta$Gbinding value more negative than the standards, SAHA and trichostatin A (TSA). That ligands were analyzed based on the nature of QSAR, pharmacological and ADME-Tox. It is conducted to obtain a potent inhibitor of HDAC class II Homo sapiens. The screening process result gave one best ligand, Nova2 (513246-99-6), which was then further studied by molecular dynamics simulations.
Advances in Bioinformatics 08/2014; 7(3):1-10. DOI:10.1155/2014/104823
"Boric acid in concentrations similar to that in blood was found to inhibit the proliferation of some human prostate cancer cell lines in vitro (Barranco and Eckhert, 2004). Cervical smears of 472 women with a high mean boron intake (8.41 mg/day) and 587 with marginal mean boron intake (1.26 mg/day) identified 15 cases of cytopathological indications of cervical cancer in boron-low women and none in the boron-high women (Korkmaz et al., 2007). In a study of 763 women with lung cancer and 838 matched healthy controls, boron intake was inversely associated with the incidence of cancer; odds increased substantially if they were not on hormone replacement therapy (Mahabir et al., 2008). "
[Show abstract][Hide abstract] ABSTRACT: This review presents current knowledge about the essentiality, biochemical function, beneficial actions, deficiency signs, absorption, transport, retention, excretion, and nutritional importance of the trace and ultra trace elements manganese, molybdenum, boron, chromium, arsenic, fluoride, nickel, silicon, strontium, and vanadium in human nutrition. Although the nutritional importance of each of the elements covered in this chapter is limited, unclear, or speculative, emerging evidence indicates that some of these elements have beneficial bioactivity in nutritional or reasonable supra-nutritional amounts. They may become recognized in a manner similar to other essential nutrients provided in supra-nutritional amounts, or phytonutrients and omega-3 fatty acids in nutritional amounts, in promoting health and preventing chronic disease in humans. Therefore, future studies are needed to determine the mechanisms behind the beneficial effects, whether some effects reflect an essential function, and the dietary intakes that give optimal response.
Present Knowledge in Nutrition, 06/2012: pages 586-607; , ISBN: 9780470959176
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