Petasiphenone, a Phenol Isolated from Cimicifuga Racemosa , in vitro Inhibits Proliferation of the Human Prostate Cancer Cell Line LNCaP

Division of Clinical and Experimental Endocrinology, University of Göttingen, Göttingen, Germany.
Planta Medica (Impact Factor: 2.15). 02/2007; 73(2):184-7. DOI: 10.1055/s-2006-957081
Source: PubMed


Extracts of Cimicifuga racemosa (L.) Nutt. (syn.: Actaea racemosa L.) (CR) inhibit the proliferation of the human prostate cancer cell line LNCaP. Recently, the phenylpropanoid ester 3,4-dihydroxyphenacyl caffeate (petasiphenone, 1) was isolated from CR. This substance is a structural homologue to petasiphenol ([3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate]), a compound produced by Petasites japonicus Sieb. & Zucc. which inhibits the growth of various human leukemia cell lines. Because of the structural similarity, we examined whether 1 affects the proliferation of LNCaP cells and the secretion of prostate-specific antigen (PSA). Under basal conditions as well as under co-incubation with 10 nM estradiol [E2 or 1 nM dihydrotestosterone (DHT)], 1 dose-dependently inhibited proliferation of LNCaP cells while PSA release per cell was not altered. We report for the first time that a defined compound isolated from CR inhibits the growth of the human prostate cancer cells LNCaP.

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    • "Petasiphenol, a phenolic compound from PJ was reported to be a potent antiangiogenic agent [23]. Petasiphenone, a phenol isolated from Climicuifuga racemosa also demonstrated inhibitory effects on the proliferation of a human prostate cancer line cell [14]. However, petasitenine, a pyrrolizidine alkaloid from the young flower stalk of PJ was associated with liver cell adenoma and hemangioendothelial sarcoma in rats [9,10]. "
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