Article

A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia.

Haematologica (impact factor: 6.42). 03/2007; 92(2):260-1.
Source: PubMed

ABSTRACT We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.

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Keywords

Aiolos
 
Aiolos activity
 
deficient phosphorylation
 
malignant transformation
 
mutations
 
phosphorylation
 
restriction site
 
vitro
 

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