Article

Aggregation of cancer among relatives of never-smoking lung cancer patients.

Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
International Journal of Cancer (impact factor: 5.44). 08/2007; 121(1):111-8. DOI:10.1002/ijc.22615 pp.111-8
Source: PubMed

ABSTRACT The authors evaluated the familial aggregation of lung and other cancers in first-degree relatives of lung cancer patients self-reported to be lifetime never smokers. The data, derived from a large lung cancer case-control study, included 2,465 first-degree relatives of 316 never smoker lung cancer cases and 2,441 first-degree relatives of 318 never smoker controls, frequency matched to the cases on age, gender and ethnicity. The median age of the cases and the controls was 61 years, about 2/3 were women, and about 80% were Caucasian. Overall, there was a 25% excess risk [95% CI (1.05-1.50)] of any type of cancer among the first-degree relatives of cases, and case offspring exhibited a 2-fold excess cancer risk (1.03-4.10) compared with control offspring. There was also a 44% excess risk (1.05-1.97) of young onset cancers (before age 50) among relatives of cases. Smoking case relatives had an increased risk of any cancer [odds ratio (OR) = 1.36 (1.03-1.81)] and a 5.52-fold risk (1.19-25.51) of young onset lung cancer compared with smoking control relatives. Female case relatives had a 58% excess breast cancer risk (1.04-2.43), and case mothers a 2.57-fold breast cancer risk (1.16-4.24). A significant excess of testicular cancer was observed among case male relatives [OR = 12.32 (1.71-88.90)], although based on only 9 cases. The age at lung cancer diagnosis tended to be earlier in case relatives (61.4, SD = 12.9) compared with control relatives (66.2, SD = 11.4; p = 0.07). Our analysis provides further evidence for the importance of genetic factors for lung cancer in never smokers.

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Keywords

2,441 first-degree relatives
 
2,465 first-degree relatives
 
2-fold excess cancer risk
 
44% excess risk
 
58% excess breast cancer risk
 
9 cases
 
cancer [odds ratio
 
case mothers
 
case offspring exhibited
 
control offspring
 
large lung cancer case-control study
 
lung cancer
 
lung cancer diagnosis
 
lung cancer patients self-reported
 
significant excess
 
Smoking case relatives
 
smoking control relatives
 
testicular cancer
 
young onset cancers
 
young onset lung cancer