Algorithm for complementary and alternative medicine practice and research in type 2 diabetes.
ABSTRACT To develop a model to direct the prescription of nutritional and botanical medicines in the treatment of type 2 diabetes for both clinical and research purposes.
Available literature on nutritional and botanical medicines was reviewed and categorized as follows: antioxidant/anti-inflammatory; insulin sensitizer; and beta-cell protectant/insulin secretagogue. Literature describing laboratory assessment for glycemic control, insulin resistance, and beta-cell reserve was also reviewed and a clinical decision tree was developed.
Clinical algorithms were created to guide the use of nutritional and botanic medicines using validated laboratory measures of glycemic control, insulin sensitivity, and beta-cell reserve. Nutrient and botanic medicines with clinical trial research support include coenzyme Q10, carnitine, alpha-lipoic acid, N-acetylcysteine, vitamin D, vitamin C, vitamin E, chromium, vanadium, omega-3 fatty acids, cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum), and gymnema (Gymnema sylvestre).
Clinical algorithms can direct supplementation in clinical practice and provide research models for clinical investigation. Algorithms also provide a framework for integration of future evidence as it becomes available. Research funding to investigate potentially beneficial practices in complementary medicine is critically important for optimal patient care and safety.
- SourceAvailable from: Vadde Ramakrishna[Show abstract] [Hide abstract]
ABSTRACT: Plants have served as traditional herbal medicines for long time, and natural products make excellent leads for new drug development. These products are mostly secondary metabolites, and have become medicines, dietary supplements, and other useful commercial products. These active lead compounds can also be further modified to enhance the biological profiles and developed as clinical trial candidates. The efficacy and safety of any pharmaceutical product is determined by the components (desired and undesired) which it contains. Mixture of compounds produced by plants may provide important combination therapies that simultaneously affect multiple pharmacological targets and provide clinical efficacy beyond the reach of single compound-based drugs. Developing innovative scientific methods for discovery, validation, characterization and standardization of these components is essential to their acceptance into mainstream medicine. In this review, we focus on latest developments in plant products research at global level with special reference to safety, efficacy and preclinical evaluation for various diseases that are reported in different laboratories.01/2009: chapter Comp. Bio. Nat. Pro. Vol III;
- Journal of Diabetes & Metabolic Disorders. 01/2014; 13(1):81.