Algorithm for complementary and alternative medicine practice and research in type 2 diabetes.
ABSTRACT To develop a model to direct the prescription of nutritional and botanical medicines in the treatment of type 2 diabetes for both clinical and research purposes.
Available literature on nutritional and botanical medicines was reviewed and categorized as follows: antioxidant/anti-inflammatory; insulin sensitizer; and beta-cell protectant/insulin secretagogue. Literature describing laboratory assessment for glycemic control, insulin resistance, and beta-cell reserve was also reviewed and a clinical decision tree was developed.
Clinical algorithms were created to guide the use of nutritional and botanic medicines using validated laboratory measures of glycemic control, insulin sensitivity, and beta-cell reserve. Nutrient and botanic medicines with clinical trial research support include coenzyme Q10, carnitine, alpha-lipoic acid, N-acetylcysteine, vitamin D, vitamin C, vitamin E, chromium, vanadium, omega-3 fatty acids, cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum), and gymnema (Gymnema sylvestre).
Clinical algorithms can direct supplementation in clinical practice and provide research models for clinical investigation. Algorithms also provide a framework for integration of future evidence as it becomes available. Research funding to investigate potentially beneficial practices in complementary medicine is critically important for optimal patient care and safety.
- SourceAvailable from: Wendy Weissner
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- "However, recent in-vitro and in-vivo research has discovered new potential properties of several cinnamon species. • The treatment of diabetes (type 2) seems to be the most promising field of research for cinnamon     . Although there are conflicting results from two randomized studies, the results from in-vitro and animal studies indicate significant hypoglycemic effects. "
ABSTRACT: An evidence-based systematic review of cinnamon (Cinnamomum spp.), including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing, by the Natural Standard Research Collaboration is discussed in this monograph.Journal of Dietary Supplements 12/2011; 8(4):378-454. DOI:10.3109/19390211.2011.627783
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- "A large number of natural products from 800 to 1200 plants are currently demonstrating hypoglycemic activity. Research and development efforts in this particular area are largely restricted to traditional medicine and in future research may identify a potent antidiabetic agent (Heber, 2003; Bradley et al., 2007; Rodriguez- Fragoso et al., 2008 "
ABSTRACT: Plants have served as traditional herbal medicines for long time, and natural products make excellent leads for new drug development. These products are mostly secondary metabolites, and have become medicines, dietary supplements, and other useful commercial products. These active lead compounds can also be further modified to enhance the biological profiles and developed as clinical trial candidates. The efficacy and safety of any pharmaceutical product is determined by the components (desired and undesired) which it contains. Mixture of compounds produced by plants may provide important combination therapies that simultaneously affect multiple pharmacological targets and provide clinical efficacy beyond the reach of single compound-based drugs. Developing innovative scientific methods for discovery, validation, characterization and standardization of these components is essential to their acceptance into mainstream medicine. In this review, we focus on latest developments in plant products research at global level with special reference to safety, efficacy and preclinical evaluation for various diseases that are reported in different laboratories.01/2009: chapter Comp. Bio. Nat. Pro. Vol III;