A male Grant's Zebra (Equus burchelli boehmi) housed with two mares at the Indianapolis Zoo had a 9-yr history of intermittent aggressive behavior toward mares and other animals. Periods of separation allowed the mares time to heal after sustaining superficial bite wounds. On 26 March 2003, the male (890293) was started on altrenogest at a dosage of 19.8 mg orally once daily to allow reintroduction. The dosage was doubled (40 mg once a day) because of a perceived lack of response. Reintroduction to the mares occurred on 17 May 2003 with no signs of aggression noted. Treatment was reduced to 19.8 mg orally once a day and then discontinued. Altrenogest was restarted at 39.5 mg orally once a day because of the planned introduction of a new mare. There have been no major aggressive displays at this dosage of altrenogest and the dosage has recently been reduced following successful introduction of a new mare.
"Gage (2005) found that a female American badger (Taxidea taxus) who intermittently displayed anxiety and self mutilation, did not display any of the abnormal behaviors during treatment with buspirone, an anti-anxiety medication. An aggressive male Grant's zebra was treated with altrenogest, and Zehnder et al. (2006) found that though an initial low dose seemed to have no effect, a higher dose, later lowered, appeared to resolve the aggression. Though pharmacological treatments can be quite effective in reduction of adverse behaviors, they are usually not a permanent solution (e.g. when drug treatment stops, the detrimental behaviors return). "
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