Article

Coumarins from Cnidium monnieri and their antiosteoporotic activity.

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China.
Planta Medica (impact factor: 2.15). 02/2007; 73(1):13-9. DOI:10.1055/s-2006-951724 pp.13-9
Source: PubMed

ABSTRACT Bioactivity-guided fractionation has led to the successful isolation of antiosteoporotic components, i. e., osthole, imperatorin and bergapten from an ethanolic extract of the fruits of Cnidium monnieri (L.) Cusson. Among them, osthole was determined as the major compound possessing antiosteoporotic activity. Further study showed that osthole not only promoted the proliferation and activity of alkaline phosphatase of osteoblasts in neonatal calvaria cultures, but also inhibited the bone resorption by decreasing the formation, differentiation and TRAP activity of osteoclasts derived from rat marrow cells.

0 0
 · 
0 Bookmarks
 · 
66 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

antiosteoporotic components
 
Bioactivity-guided fractionation
 
bone resorption
 
Cnidium monnieri
 
decreasing
 
ethanolic
 
imperatorin
 
major compound
 
neonatal calvaria cultures
 
osteoblasts
 
proliferation
 
rat marrow cells
 
TRAP activity