Impact of maternal substance use during pregnancy on childhood outcome

Wayne State University School of Medicine, Detroit, MI, USA. <>
Seminars in Fetal and Neonatal Medicine (Impact Factor: 3.03). 05/2007; 12(2):143-50. DOI: 10.1016/j.siny.2007.01.002
Source: PubMed


The impact of maternal substance abuse is reflected in the 2002-2003 National Survey on Drug Use and Health. Among pregnant women in the 15-44 age group, 4.3%, 18% and 9.8% used illicit drugs, tobacco and alcohol, respectively. Maternal pregnancy complications following substance use include increases in sexually transmitted disorders, placental abruption and HIV-positive status. Effects on the neonate include a decrease in growth parameters and increases in central nervous system and autonomic nervous system signs and in referrals to child protective agencies. In childhood, behavioral and cognitive effects are seen after prenatal cocaine exposure; tobacco and alcohol have separate and specific effects. The ongoing use of alcohol and tobacco by the caretaker affects childhood behavior. Therefore, efforts should be made to prevent and treat behavioral problems as well as to limit the onset of drug use by adolescent children born to women who use drugs during pregnancy.

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Available from: Charles R Bauer, Oct 06, 2015
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    • "). Drug or alcohol use during pregnancy can have a negative impact medically and socially on both the mother and newborn (Shankaran et al., 2007; Terplan & Wright, 2011). Integrated treatment during pregnancy as well as early intervention for the newborn can ameliorate these negative effects (Meyer et al., 2012; Niccols et al., 2012; Peadon, Rhys-Jones, Bower, & Elliott, 2009). "
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    ABSTRACT: Recent amendments to the Child Abuse Prevention and Treatment Act tie the receipt of federal block grants to mandatory reporting of substance-exposed newborns. To determine rates of screening, testing, and reporting of drug and alcohol use at the time of delivery, we administered a telephone survey of nursing managers and perinatal social workers at Maryland birthing hospitals. Of the 34 hospitals, 31 responded (response rate 91%). Although 97% of hospitals reported universal screening, only 6% used a validated instrument. Testing was reported by 94% with 45% reporting universal maternal testing and 7% universal newborn testing. Only 32% reported obtaining maternal consent prior to testing. There is significant heterogeneity in screening and testing for substance use in birthing hospitals. Given federal reporting mandates, state-level practices need to be standardized.
    Social Work in Health Care 08/2014; 53(7):659-669. DOI:10.1080/00981389.2014.916375 · 0.62 Impact Factor
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    • "The epidemic of cocaine use [Elliot and Coker, 1991] has raised significant public attention to adolescents prenatally exposed to cocaine [Derauf et al., 2009; Frank et al., 2001; Lester and Padbury, 2009; Shankaran et al., 2007]. Prenatal cocaine exposure (PCE) affected adolescents are associated with deficits in intelligence, language skills, executive Liu, 2011; Zhu et al., 2011, 2012, in press]. "
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    ABSTRACT: Recent in vivo neuroimaging studies revealed that several brain networks are altered in prenatal cocaine exposure (PCE) affected adolescent brains. However, due to a lack of dense and corresponding cortical landmarks across individuals, the systematical alterations of functional connectivities in large-scale brain networks and the alteration of structural brain architecture in PCE affected brain are largely unknown. In this article, we adopted a newly developed data-driven strategy to build a large set of cortical landmarks that are consistent and corresponding across PCE adolescents and their matched controls. Based on these landmarks, we constructed large-scale functional connectomes and applied the well-established approaches of deriving genomics signatures in genome-wide gene expression studies to discover functional connectomics signatures for the characterization of PCE adolescent brains. Results derived from experimental data demonstrated that 10 structurally disrupted landmarks were identified in PCE, and more importantly, the discovered informative functional connectomics signatures among consistent landmarks distinctively differentiate PCE brains from their matched controls. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
    Human Brain Mapping 10/2013; 34(10). DOI:10.1002/hbm.22082 · 5.97 Impact Factor
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    • "In our study cohort there were no differences in maternal age or in the number of mothers with hypertension and gestational diabetes, therefore the changes observed in the placental circulation must be attributed to the effects of the drugs of abuse. Substance abuse by pregnant women has been associated with a decrease of prenatal care, maternal malnutrition and increased incidence of infections such as HBV or HCV, HIV and other sexually transmitted diseases [10] [13] [17] [52] [53]. The results of our study also point in this direction. "
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    ABSTRACT: The aim of the study was to find morphological changes in the feto-placental unit due to prenatal exposure to drugs of abuse. A blind histomorphometric study was performed using 225 placentas. Based on meconium testing, the fetuses were classified as exposed or unexposed to opiates, cocaine, cannabis or alcohol. To establish prenatal tobacco exposure, cotinine in cord blood was analyzed. At the microscopic level a non statistically significant reduction of placental vascularization was observed in cocaine, opiates and alcohol using mothers. In addition, alcohol-consuming mothers did not present with larger placental vessel diameter than controls. Prenatal use of cocaine and tobacco was associated with a decrease in newborn weight and length. Furthermore, tobacco use was associated with a higher rate of previous abortions. In conclusion, placentas from mothers using tobacco, cocaine, opiates or alcohol during pregnancy present vasculature changes that may explain the adverse perinatal outcomes in their newborns.
    Reproductive Toxicology 04/2012; 34(1):73-9. DOI:10.1016/j.reprotox.2012.04.002 · 3.23 Impact Factor
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