Alcohol consumption, bone density, and hip fracture among older adults: The cardiovascular health study

Department of Public Health, Cornell University, Итак, New York, United States
Osteoporosis International (Impact Factor: 4.17). 06/2007; 18(5):593-602. DOI: 10.1007/s00198-006-0287-7
Source: PubMed


Previous studies have found inconsistent relationships of alcohol consumption with risk of hip fracture, and the importance of bone mineral density and risk of falls in mediating such a relationship has not been determined.
As part of the Cardiovascular Health Study, a population-based cohort study of adults aged 65 years and older from four U.S. communities, 5,865 participants reported their use of beer, wine, and liquor yearly. We identified cases of hip fracture unrelated to malignancy or motor vehicle accidents using hospitalization discharge diagnoses. A subgroup of 1,567 participants in two communities underwent dual-energy x-ray absorptiometry scans to assess bone mineral density.
A total of 412 cases of hip fracture occurred during an average of 12 years of follow-up. There was a significant U-shaped relationship between alcohol intake and risk of hip fracture (p quadratic 0.02). Compared with long-term abstainers, the adjusted hazard ratios for hip fracture were 0.78 (95% confidence interval [CI], 0.61-1.00) among consumers of up to 14 drinks per week and 1.18 (95% CI, 0.77-1.81) among consumers of 14 or more drinks per week. Alcohol intake was associated with bone mineral density of the total hip and femoral neck in a stepwise manner, with approximately 5% (95% CI, 1%-9%) higher bone density among consumers of 14 or more drinks per week than among abstainers. These relationships were all similar among men and women.
Among older adults, moderate alcohol consumption has a U-shaped relationship with risk of hip fracture, but a graded positive relationship with bone mineral density at the hip.

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    • "Although their primary objective was assessing amount of alcohol consumed, Mukamal et al. also examined beer, wine, and liquor consumption in 5,865 participants in the Cardiovascular Health Study. They included 0 (reference), <1, 1–6, and 7+ drinks per week categories for beer, wine, and liquor and noted that no type was significantly associated with hip fracture [20]. The HR for 1–6 drinks per week of wine was 0.75 (95% CI 0.48-1.17), "
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    ABSTRACT: Past studies of relationships between alcohol and hip fracture have generally focused on total alcohol consumed and not type of alcohol. Different types of alcohol consist of varying components which may affect risk of hip fracture differentially. This study seeks to examine the relationship between alcohol consumption, with a focus on type of alcohol consumed (e.g. beer, wine, or hard liquor) and hip fracture risk in post-menopausal women. The longitudinal cohort consisted of U.S. post-menopausal women aged 50--79 years enrolled between 1993--1998 in the Women's Health Initiative Clinical Trials and Observational Study (N=115,655). Women were categorized as non-drinkers, past drinkers, infrequent drinkers and drinkers by preference of alcohol type (i.e. those who preferred wine, beer, hard liquor, or who had no strong preference). Mean alcohol consumption among current drinkers was 3.3 servings per week; this was similar among those who preferred wine, beer and liquor. After adjustment for potential confounders, alcohol preference was strongly correlated with hip fracture risk (p = 0.0167); in particular, women who preferred wine were at lower risk than non-drinkers (OR=0.78; 95% CI 0.64-0.95), past drinkers (OR=0.85; 95% CI 0.72-1.00), infrequent drinkers (OR=0.73; 95% CI 0.61-0.88), hard liquor drinkers (OR=0.87; 95% CI 0.71-1.06), beer drinkers (OR=0.72; 95% CI 0.55-0.95)and those with no strong preference (OR=0.89; 95% CI 0.89; 95% CI 0.73-1.10). Preference of alcohol type was associated with hip fracture; women who preferentially consumed wine had a lower risk of hip fracture compared to non-drinkers, past drinkers, and those with other alcohol preferences.
    BMC Women's Health 09/2013; 13(1):36. DOI:10.1186/1472-6874-13-36 · 1.50 Impact Factor
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    • "Proximal femur fractures have been acknowledged as a sign of osteoporosis for more than 150 years (Cooper, 1822). Currently, nearly all hip fractures occur as an outcome of a fall by an individual with reduced bone strength (Melton et al., 2003; Physician&apos;s Guide, 2003; Di Monaco et al., 2006; Mukamal et al., 2007). As such, it is probable that at least some of the described hip fractures are a consequence of bone loss. "
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    ABSTRACT: Fractures are ubiquitous in the archaeological record but the majority of these are the consequence of a traumatic incident and do not reflect any loss of strength inherent to the bone. So-called fragility fractures, particularly hip fractures, are considered uncommon occurrences in skeletal populations from the past. Nevertheless, evidence of this type of fracture in the archaeological record is increasing. A methodical search for possible hip fractures in the excavation reports, theses and monographs housed in the Department of Anthropology of the University of Coimbra presented an occasion to describe six hip fractures, previously unpublished, from different Portuguese archaeological sites and to challenge the widespread assumption that hip fractures were nearly non-existent in the past.
    Anthropological Science 01/2011; 119(1-1):87-93. DOI:10.1537/Ase.100211 · 0.61 Impact Factor
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    ABSTRACT: Emeritus of Food Science and Nutrition from Arizona State University, has decades of experience in food science and nutrition as a researcher, teacher, inventor, industry consultant and consumer advocate who is committed to food additive safety and the prevention of food borne diseases. For over 30 years he has studied the link between artificial sweeteners and the diseases of civilization including Alzheimer's, Heart Disease, Multiple Sclerosis, numerous forms of cancer, Autism and other Birth Defects. Dr. Monte's testimony before Congress was instrumental in the prevention of Sulfites from receiving status of US FDA GRAS (Generally Regarded As Safe) and the implementation of mandatory labeling for most foods that contain this dangerous additive. Through his research, Dr. Monte has been awarded 22 US patents. He has shared his technical expertise during hundreds of television and radio appearances including a spe-cial feature on the CBS Evening News with Dan Rather and 60 Minutes. He is the author of numerous scientific publications and the book While Science Sleeps: A Sweetener Kills.
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